Title :

Exposure to atmospheric ultrafine particles induces severe lung inflammatory response and tissue remodeling in mice

Author(s) :

Saleh, Yara [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Anthérieu, Sébastien [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Dusautoir, Romain [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Alleman, Laurent [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Sotty, Jules [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
De Sousa, Corentin [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Platel, Anne [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Perdrix, Esperanza [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Riffault, Véronique [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Fronval, Isabelle [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Nesslany, Fabrice [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Canivet, Ludivine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Garcon, Guillaume [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Lo Guidice, Jean-Marc [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
fronval [Auteur]

Journal title :

International Journal of Environmental Research and Public Health

Abbreviated title :

Int J Environ Res Public Health

Volume number :

16

Pages :

1210

Publication date :

2019-04-04

ISSN :

1660-4601

Keyword(s) :

(sub)chronic exposure
lung tissue remodeling
Ultrafine particles
mice
inflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher ...
Show more >Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Trace element and PAH analysis demonstrated the almost similar chemical composition of both particle fractions. Mice were exposed intranasally to FF or UFP according to acute (10, 50 or 100 µg of PM) and repeated (10 µg of PM 3 times a week during 1 or 3 months) exposure protocols. More particle-laden macrophages and even greater chronic inflammation were observed in the UFP-exposed mice lungs. Histological analyses revealed that about 50% of lung tissues were damaged in mice exposed to UFP for three months versus only 35% in FF-exposed mice. These injuries were characterized by alveolar wall thickening, macrophage infiltrations, and cystic lesions. Taken together, these results strongly motivate the update of current regulations regarding ambient PM concentrations to include UFP and limit their emission.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
IMT Lille Douai
Inserm
Institut Catholique Lille
Institut Pasteur de Lille
Univ. Artois
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:23:58Z
2022-05-24T09:04:41Z