TiO2 Nanomaterials Non-Controlled Contamination ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
TiO2 Nanomaterials Non-Controlled Contamination Could Be Hazardous for Normal Cells Located in the Field of Radiotherapy
Auteur(s) :
Wang, Yidan [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Sauvat, Allan [Auteur]
Institut Gustave Roussy [IGR]
Lacrouts, Celine [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Lebeau, Jerome [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Grall, Romain [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Hullo, Marie [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Nesslany, Fabrice [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Chevillard, Sylvie [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Sauvat, Allan [Auteur]
Institut Gustave Roussy [IGR]
Lacrouts, Celine [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Lebeau, Jerome [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Grall, Romain [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Hullo, Marie [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Nesslany, Fabrice [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Chevillard, Sylvie [Auteur]
Commissariat à l'énergie atomique et aux énergies alternatives [CEA]
Titre de la revue :
International journal of molecular sciences
Nom court de la revue :
Int J Mol Sci
Numéro :
21
Pagination :
940
Éditeur :
MDPI
Date de publication :
2020-01-31
ISSN :
1422-0067
Mot(s)-clé(s) :
TiO2 nanoparticles
photocatalysis
radiation sensitivity
photocatalysis
radiation sensitivity
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Among nanomaterials (NMs), titanium dioxide (TiO2) is one of the most manufactured NMs and can be found in many consumers’ products such as skin care products, textiles and food (as E171 additive). Moreover, due to its ...
Lire la suite >Among nanomaterials (NMs), titanium dioxide (TiO2) is one of the most manufactured NMs and can be found in many consumers’ products such as skin care products, textiles and food (as E171 additive). Moreover, due to its most attractive property, a photoactivation upon non-ionizing UVA radiation, TiO2 NMs is widely used as a decontaminating agent. Uncontrolled contaminations by TiO2 NMs during their production (professional exposure) or by using products (consumer exposure) are rather frequent. So far, TiO2 NMs cytotoxicity is still a matter of controversy depending on biological models, types of TiO2 NMs, suspension preparation and biological endpoints. TiO2 NMs photoactivation has been widely described for UV light radiation exposure, it could lead to reactive oxygen species production, known to be both cyto- and genotoxic on human cells. After higher photon energy exposition, such as X-rays used for radiotherapy and for medical imaging, TiO2 NMs photoactivation still occurs. Importantly, the question of its hazard in the case of body contamination of persons receiving radiotherapy was never addressed, knowing that healthy tissues surrounding the tumor are indeed exposed. The present work focuses on the analysis of human normal bronchiolar cell response after co-exposition TiO2 NMs (with different coatings) and ionizing radiation. Our results show a clear synergistic effect, in terms of cell viability, cell death and oxidative stress, between TiO2 NMS and radiationLire moins >
Lire la suite >Among nanomaterials (NMs), titanium dioxide (TiO2) is one of the most manufactured NMs and can be found in many consumers’ products such as skin care products, textiles and food (as E171 additive). Moreover, due to its most attractive property, a photoactivation upon non-ionizing UVA radiation, TiO2 NMs is widely used as a decontaminating agent. Uncontrolled contaminations by TiO2 NMs during their production (professional exposure) or by using products (consumer exposure) are rather frequent. So far, TiO2 NMs cytotoxicity is still a matter of controversy depending on biological models, types of TiO2 NMs, suspension preparation and biological endpoints. TiO2 NMs photoactivation has been widely described for UV light radiation exposure, it could lead to reactive oxygen species production, known to be both cyto- and genotoxic on human cells. After higher photon energy exposition, such as X-rays used for radiotherapy and for medical imaging, TiO2 NMs photoactivation still occurs. Importantly, the question of its hazard in the case of body contamination of persons receiving radiotherapy was never addressed, knowing that healthy tissues surrounding the tumor are indeed exposed. The present work focuses on the analysis of human normal bronchiolar cell response after co-exposition TiO2 NMs (with different coatings) and ionizing radiation. Our results show a clear synergistic effect, in terms of cell viability, cell death and oxidative stress, between TiO2 NMS and radiationLire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Institut Pasteur de Lille
Université de Lille
Date de dépôt :
2022-02-02T10:24:32Z
2022-10-05T06:30:43Z
2022-10-05T06:30:43Z
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- Wang et al.pdf
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