Human poisoning from poisonous higher ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
URL permanente :
Titre :
Human poisoning from poisonous higher fungi: focus on analytical toxicology and case reports in forensic toxicology
Auteur(s) :
Flament, Estelle [Auteur]
Guitton, Jerome [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Laboratoire de Pharmacologie et Toxicologie
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaillard, Yvan [Auteur]
Guitton, Jerome [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Laboratoire de Pharmacologie et Toxicologie
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaillard, Yvan [Auteur]
Titre de la revue :
Pharmaceuticals (Basel, Switzerland)
Nom court de la revue :
Pharmaceuticals (Basel)
Numéro :
13
Pagination :
454
Éditeur :
MDPI
Date de publication :
2020-12-11
ISSN :
1424-8247
Mot(s)-clé(s) :
analytical toxicology
mushroom poisoning
mycotoxins
orellanine
forensic toxicology
amatoxins
mushroom poisoning
mycotoxins
orellanine
forensic toxicology
amatoxins
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Several families of higher fungi contain mycotoxins that cause serious or even fatal poisoning when consumed by humans. The aim of this review is to inventory, from an analytical point of view, poisoning cases linked with ...
Lire la suite >Several families of higher fungi contain mycotoxins that cause serious or even fatal poisoning when consumed by humans. The aim of this review is to inventory, from an analytical point of view, poisoning cases linked with certain significantly toxic mycotoxins: orellanine, α- and β-amanitin, muscarine, ibotenic acid and muscimol, and gyromitrin. Clinicians are calling for the cases to be documented by toxicological analysis. This document is therefore a review of poisoning cases involving these mycotoxins reported in the literature and carries out an inventory of the analytical techniques available for their identification and quantification. It seems indeed that these poisonings are only rarely documented by toxicological analysis, due mainly to a lack of analytical methods in biological matrices. There are many reasons for this issue: the numerous varieties of mushroom involved, mycotoxins with different chemical structures, a lack of knowledge about distribution and metabolism. To sum up, we are faced with (i) obstacles to the documentation and interpretation of fatal (or non-fatal) poisoning cases and (ii) a real need for analytical methods of identifying and quantifying these mycotoxins (and their metabolites) in biological matrices.Lire moins >
Lire la suite >Several families of higher fungi contain mycotoxins that cause serious or even fatal poisoning when consumed by humans. The aim of this review is to inventory, from an analytical point of view, poisoning cases linked with certain significantly toxic mycotoxins: orellanine, α- and β-amanitin, muscarine, ibotenic acid and muscimol, and gyromitrin. Clinicians are calling for the cases to be documented by toxicological analysis. This document is therefore a review of poisoning cases involving these mycotoxins reported in the literature and carries out an inventory of the analytical techniques available for their identification and quantification. It seems indeed that these poisonings are only rarely documented by toxicological analysis, due mainly to a lack of analytical methods in biological matrices. There are many reasons for this issue: the numerous varieties of mushroom involved, mycotoxins with different chemical structures, a lack of knowledge about distribution and metabolism. To sum up, we are faced with (i) obstacles to the documentation and interpretation of fatal (or non-fatal) poisoning cases and (ii) a real need for analytical methods of identifying and quantifying these mycotoxins (and their metabolites) in biological matrices.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Institut Pasteur de Lille
Université de Lille
Date de dépôt :
2022-02-02T10:24:46Z
2022-10-12T09:57:10Z
2023-02-07T14:26:38Z
2022-10-12T09:57:10Z
2023-02-07T14:26:38Z
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- Flament et al.pdf
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