Title :

Multinuclear nmr in polypeptide liquid crystals: three fertile decades of methodological developments and analytical challenges

Author(s) :

Lesot, Philippe [Auteur]
Aroulanda, Christie [Auteur]
Berdague, Philippe [Auteur]
Meddour, Abdelkrim [Auteur]
Merlet, Denis [Auteur]
Farjon, Jonathan [Auteur]
Giraud, Nicolas [Auteur]
Lafon, Olivier [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Journal title :

Progress in nuclear magnetic resonance spectroscopy

Abbreviated title :

Prog Nucl Magn Reson Spectrosc

Volume number :

116

Pages :

85-154

Publication date :

2020-02-01

ISSN :

1873-3301

Keyword(s) :

Anisotropic NMR
Stereochemistry
Analytical applications
Spectral enantiodetection
Polypeptide oriented media

HAL domain(s) :

Chimie/Catalyse

English abstract : [en]

NMR spectroscopy of oriented samples makes accessible residual anisotropic intramolecular NMR interactions, such as chemical shift anisotropy (RCSA), dipolar coupling (RDC), and quadrupolar coupling (RQC), while preserving ...
Show more >NMR spectroscopy of oriented samples makes accessible residual anisotropic intramolecular NMR interactions, such as chemical shift anisotropy (RCSA), dipolar coupling (RDC), and quadrupolar coupling (RQC), while preserving high spectral resolution. In addition, in a chiral aligned environment, enantiomers of chiral molecules or enantiopic elements of prochiral compounds adopt different average orientations on the NMR timescale, and hence produce distinct NMR spectra or signals. NMR spectroscopy in chiral aligned media is a powerful analytical tool, and notably provides unique information on (pro)chirality analysis, natural isotopic fractionation, stereochemistry, as well as molecular conformation and configuration. Significant progress has been made in this area over the three last decades, particularly using polypeptide-based chiral liquid crystals (CLCs) made of organic solutions of helically chiral polymers (as PBLG) in organic solvents. This review presents an overview of NMR in polymeric LCs. In particular, we describe the theoretical tools and the major NMR methods that have been developed and applied to study (pro)chiral molecules dissolved in such oriented solvents. We also discuss the representative applications illustrating the analytical potential of this original NMR tool. This overview article is dedicated to thirty years of original contributions to the development of NMR spectroscopy in polypeptide-based chiral liquid crystals.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

RMN et matériaux inorganiques (RM2I)

Submission date :

2022-03-02T07:14:23Z