Fine-tuned regulation of stress priming ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Fine-tuned regulation of stress priming and thermotolerance
Author(s) :
Pfeuty, Benjamin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]
Thommen, Quentin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]
Thommen, Quentin [Auteur]
Journal title :
Physical Biology
Publisher :
Institute of Physics: Hybrid Open Access
Publication date :
2020-02-02
ISSN :
1478-3967
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool ...
Show more >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Show less >
Show more >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Show less >
Language :
Anglais
Popular science :
Non
Source :
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