Fine-tuned regulation of stress priming and thermotolerance

Pfeuty, Benjamin; Courtade, Emmanuel; Thommen, Quentin

Type de document :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1101/2021.01.27.428215

Titre :

Fine-tuned regulation of stress priming and thermotolerance

Auteur(s) :

Pfeuty, Benjamin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]

Thommen, Quentin [Auteur]

Titre de la revue :

Physical Biology

Éditeur :

Institute of Physics: Hybrid Open Access

Date de publication :

2020-02-02

ISSN :

1478-3967

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool ...
Lire la suite >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523

Source :

Harvested from HAL

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