Fine-tuned regulation of stress priming ...
Type de document :
Compte-rendu et recension critique d'ouvrage
Titre :
Fine-tuned regulation of stress priming and thermotolerance
Auteur(s) :
Pfeuty, Benjamin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]
Thommen, Quentin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]
Thommen, Quentin [Auteur]
Titre de la revue :
Physical Biology
Éditeur :
Institute of Physics: Hybrid Open Access
Date de publication :
2020-02-02
ISSN :
1478-3967
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool ...
Lire la suite >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Lire moins >
Lire la suite >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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- https://www.biorxiv.org/content/biorxiv/early/2021/01/27/2021.01.27.428215.full.pdf
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- https://www.biorxiv.org/content/biorxiv/early/2021/01/27/2021.01.27.428215.full.pdf
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- https://www.biorxiv.org/content/biorxiv/early/2021/01/27/2021.01.27.428215.full.pdf
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