Fine-tuned regulation of stress priming and thermotolerance

Pfeuty, Benjamin; Courtade, Emmanuel; Thommen, Quentin

Document type :

Article dans une revue scientifique

DOI :

10.1101/2021.01.27.428215

Title :

Fine-tuned regulation of stress priming and thermotolerance

Author(s) :

Pfeuty, Benjamin [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Courtade, Emmanuel [Auteur]

Thommen, Quentin [Auteur]

Journal title :

Physical Biology

Publisher :

Institute of Physics: Hybrid Open Access

Publication date :

2020-02-02

ISSN :

1478-3967

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool ...
Show more >A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523

Source :

Harvested from HAL

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