Title :

FDG PET/CT allowing detection and follow-up of tumor cell transplantation

Author(s) :

Jaillard, Alice [Auteur]
CIC CHU ( Lille)/inserm
Baillet, Clio [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Beron, Amandine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tabibzadeh, Nahid [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Scherpereel, Arnaud [Auteur]
Hôpital Albert Calmette
Frimat, Marie [Auteur]
Hôpital Claude Huriez [Lille]
Perbet, Romain [Auteur]
Service d'oncologie médicale (CHRU Lille)
Gnemmi, Viviane [Auteur]
CIC CHU ( Lille)/inserm
Noel, Christian [Auteur]
Hôpital Claude Huriez [Lille]
Huglo, Damien [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]

Journal title :

Annals of Nuclear Medicine

Pages :

250-254

Publisher :

Springer Verlag

Publication date :

2016-04-01

ISSN :

0914-7187

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed ...
Show more >After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed abnormal increased uptake of the renal graft, associated with hypermetabolic lymph nodes and hepatic, pulmonary and bone lesions. Emergency graft resection was performed 5 days after PET/CT, permitting immunosuppressive therapy withdrawal. Pathologic examination of the kidney showed parenchymal infiltration by tumor cells compatible with small cell lung cancer. Thereafter, pathologists proved that the recipient's and donor's tumor cells matched using microsatellite markers. FDG-PET/CT was performed in the follow-up and showed progression in the donor despite chemotherapy and radiotherapy. He died a few months later. However, FDG-PET/CT showed a complete metabolic response after only 3 courses of chemotherapy in the recipient.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL