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Evaluation of Pentravan (R), Pentravan (R) ...
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Document type :
Article dans une revue scientifique
DOI :
10.1016/j.ijpharm.2016.11.014
PMID :
27826027
Permalink :
http://hdl.handle.net/20.500.12210/4357
Title :
Evaluation of Pentravan (R), Pentravan (R) Plus, Phytobase (R), Lipovan (R) and Pluronic Lecithin Organogel for the transdermal administration of antiemetic drugs to treat chemotherapy-induced nausea and vomiting at the hospital
Author(s) :
Bourdon, F [Auteur]
Lecoeur, Marie [Auteur] refId
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Leconte, L [Auteur]
Ultre, V [Auteur]
Kouach, Mostafa [Auteur]
Odou, Pascal [Auteur] refId
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Vaccher, Claude [Auteur] refId
Foulon, Catherine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Journal title :
International journal of pharmaceutics
Abbreviated title :
Int. J. Pharm.
Volume number :
515
Pages :
774-787
Publication date :
2016
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The objective of this study was to evaluate five commercial ready-to-use transdermal vehicles (Phytobase®, Lipovan®, Pentravan®, Pentravan® Plus and Pluronic Lecithin Organogel (PLO)), for the compounding of three antiemetic ...
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The objective of this study was to evaluate five commercial ready-to-use transdermal vehicles (Phytobase®, Lipovan®, Pentravan®, Pentravan® Plus and Pluronic Lecithin Organogel (PLO)), for the compounding of three antiemetic drugs (ondansetron, dexamethasone and aprepitant) and their administration in combination to treat chemotherapy-induced nausea and vomiting (CINV) at the hospital. Drugs were individually formulated in these vehicles and in mixture in Pentravan® Plus using different penetration enhancers. Quality control of the forms has demonstrated that formulation process was mastered and convenient for the hospital (time required: 20min). Diffusion experiments through synthetic membranes and pig ear epidermis performed using Franz-type diffusion cells, have shown that the release and permeation process were greater for ondansetron than for dexamethasone and aprepitant, with a release step not limiting. As permeation of aprepitant was too low, it was discarded of the study. When ondansetron and dexamethasone were compounded in combination in Pentravan® Plus, the most efficient vehicle, a permeation decrease was observed. Finally, the use of tween 20 instead of EtOH as chemical enhancer has led to 2-fold factor increase in the flux of dexamethasone, resulting in fluxes convenient for transdermal administration of ondansetron to a child, but insufficient for an adult and for dexamethasone.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
Inserm
Collections :
  • Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Research team(s) :
Innovation/évaluation des médicaments injectables
Modélisation biopharmaceutique et pharmacocinétique
Submission date :
2019-02-26T17:07:20Z
Université de Lille

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