Titre :

Prognostic Impact of Surgical Margins for Hepatocellular Carcinoma According to Preoperative Alpha-Fetoprotein Level.

Auteur(s) :

Marques, Frédéric [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Ghallab, Mohammed [Auteur]
Queens Elizabeth Hospital [Birmingham]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Vibert, Eric [Auteur]
Physiopathologie et traitement des maladies du foie
Boleslawski, Emmanuel [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Soubrane, Olivier [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Hôpital Beaujon [AP-HP]
Adam, René [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Farges, Olivier [Auteur]
Hôpital Beaujon [AP-HP]
Mabrut, Jean-Yves [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Regimbeau, Jean-Marc [Auteur]
Simplification des soins chez les patients complexes - UR UPJV 7518 [SSPC]
Chirurgie digestive [CHU Amiens]
Cherqui, Daniel [Auteur]
Hôpital Paul Brousse
Allard, Marc-Antoine [Auteur]
Université Paris-Saclay
Hôpital Paul Brousse
Sa Cunha, Antonio [Auteur]
Modèles de Cellules Souches Malignes et Thérapeutiques [ONCOSTEM]
Hôpital Paul Brousse
Université Paris-Saclay
Samuel, Didier [Auteur]
Physiopathologie et traitement des maladies du foie
Pruvot, François-René [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Golse, Nicolas [Auteur]
SImulations en Médecine, BIOtechnologie et ToXicologie de systèmes multicellulaires [SIMBIOTX]
Centre d'Etudes et de Recherche en Droit de l'Immatériel [CERDI]

Titre de la revue :

HPB

Pagination :

848--856

Éditeur :

Elsevier

Date de publication :

2022

ISSN :

1365-182X

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

Résumé en anglais : [en]

BACKGROUND: HCC are known to have satellite nodules and microvascular invasions requiring sufficient margins. An alpha-fetoprotein (AFP) level >100 ng/mL is associated with worse pathological features in HCC. In practice, ...
Lire la suite >BACKGROUND: HCC are known to have satellite nodules and microvascular invasions requiring sufficient margins. An alpha-fetoprotein (AFP) level >100 ng/mL is associated with worse pathological features in HCC. In practice, large resection margins, particularly >1~cm, are infrequently retrieved on the specimens. METHODS: 397 patients from 5 centres were included from 2012 to 2017. The primary endpoint was time-to-recurrence in relation to AFP level (> or <100 ng/ml) as well as surgical margins (> or <1 cm). The secondary endpoint was overall survival (OS). RESULTS: The median follow-up was 25 months. In Low AFP group, median time to recurrence (TTR) for patients with margins <1 cm was 36 months and for patients with margins ≥q1 cm was 34 months (p = 0.756), and overall survival (OS) was not significantly different according to margins (p = 0.079). In High-AFP group, patients with margins <1 cm had a higher recurrence rate than patients with margins ≥q1 cm (p = 0.016): median TTR for patients with margins <1 cm was 8 months whereas it was not reached for patients with margins ≥q1 cm. Patients with margins <1 cm had a significantly worse OS compared to the patients with margins ≥q1 cm (p = 0.043). CONCLUSION: Preoperative AFP level may help determine margins to effectively treat high AFP tumours. For low-AFP tumours, margins didn't have an impact on TTR or OS.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL