Title :

Impact of vaginal brachytherapy in intermediate and high-intermediate risk endometrial cancer: a multicenter study from the francogyn group

Author(s) :

Reboux, Pierre Alain [Auteur]
Azais, Henri [Auteur]
Canova, Charles Henry [Auteur]
Bendifallah, Sofiane [Auteur]
Ouldamer, Lobna [Auteur]
Raimond, Emilie [Auteur]
Hudry, Delphine [Auteur]
Coutant, Charles [Auteur]
Graesslin, Olivier [Auteur]
Touboul, Cyril [Auteur]
Collinet, Pierre [Auteur]
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Bricou, Alexandre [Auteur]
Huchon, Cyrille [Auteur]
Darai, Emile [Auteur]
Ballester, Marcos [Auteur]
Leveque, Jean [Auteur]
Lavoue, Vincent [Auteur]
Koskas, Martin [Auteur]
Uzan, Catherine [Auteur]
Canlorbe, Geoffroy [Auteur]

Journal title :

Journal of gynecologic oncology

Abbreviated title :

J Gynecol Oncol

Publication date :

2019-02-07

ISSN :

2005-0399

Keyword(s) :

Local Neoplasm Recurrence
Endometrial Cancer
Brachytherapy

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: According to recent European Society of Medical Oncology, European Society of Gynaecological Oncology and European Society of Radiotherapy and Oncology guidelines, adjuvant vaginal brachytherapy (VB) is optional ...
Show more >OBJECTIVE: According to recent European Society of Medical Oncology, European Society of Gynaecological Oncology and European Society of Radiotherapy and Oncology guidelines, adjuvant vaginal brachytherapy (VB) is optional in patients with intermediate risk (IR) and high-intermediate risk (HIR) endometrial cancer (EC). The aim of this French retrospective, multicenter study was to assess the impact of VB in these groups on local recurrence rate, local recurrence-free survival (RFS) and overall survival (OS). METHODS: Data of 191 patients with IR and HIR EC who underwent primary surgery with or without VB and no other adjuvant treatment between 2000 and 2016 were extracted from the FRANCOGYN database. Rate of local recurrence, OS and local RFS in these two groups were compared using the Kaplan-Meier method. RESULTS: The number of patients with IR and HIR EC were 118 and 73 respectively. VB was used in 92 patients in IR group and 43 in HIR group. Median follow-up was 22 months. In the HIR group, the local recurrence rate was significantly higher in the no adjuvant therapy group in comparison with the VB group (16.7% and 0% respectively, p=0.02). There was also a significant improvement in local RFS (p=0.01) in VB group. In IR EC, there is no significant difference on local recurrence rate (4.2% and 3.2%, respectively, p=1.00) or local RFS (p=0.54) between the two groups. CONCLUSIONS: VB is an efficient adjuvant treatment for patients with HIR EC. VB is not associated with an improvement of RFS or OS in IR EC patient.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:58:55Z