Title :

Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma

Author(s) :

Dufresne, A. [Auteur]
Lesluyes, T. [Auteur]
Menetrier-Caux, C. [Auteur]
Brahmi, M. [Auteur]
Darbo, E. [Auteur]
Toulmonde, Maud [Auteur]
Italiano, A. [Auteur]
Mir, O. [Auteur]
Le Cesne, Axel [Auteur]
Le Guellec, S. [Auteur]
Valentin, T. [Auteur]
Chevreau, C. [Auteur]
Bonvalot, S. [Auteur]
Robin, Y. M. [Auteur]
Coindre, J.-M. [Auteur]
Caux, C. [Auteur]
Blay, J. Y. [Auteur]
Chibon, F. [Auteur]

Journal title :

Oncoimmunology

Abbreviated title :

OncoImmunology

Volume number :

9

Publication date :

2020-01-01

ISSN :

2162-402X

Keyword(s) :

predictive factor
Soft tissue sarcoma
immunologic landscape
gene expression
histological diagnosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Soft tissue sarcomas are a group of rare and aggressive connective tissue neoplasms for which curative therapeutic opportunities are limited in advanced phase. Clinical trials assessing immunotherapy in these tumors have ...
Show more >Soft tissue sarcomas are a group of rare and aggressive connective tissue neoplasms for which curative therapeutic opportunities are limited in advanced phase. Clinical trials assessing immunotherapy in these tumors have so far reported limited efficacy. The objective of this study is to provide a description of the immunologic landscape of sarcomas to guide the next clinical trials of immunotherapy in these diseases. The gene expression profile of 93 immune checkpoint (ICP) and membrane markers (MM) of immune cells was analyzed in a series of 253 soft tissue sarcoma (synovial sarcoma, myxoid liposarcoma, sarcoma with complex genomic and GIST) using Agilent Whole Human Genome Microarrays. The unsupervised hierarchical clustering of gene expression level was found able to properly group patients according to the histological subgroup of sarcoma, indicating that each sarcoma subgroup is associated with a specific immune signature defined by its gene expression pattern. Using the prognostic impact of CIBERSORT signature on metastatic-free survival in each subgroup, specific target could be proposed for each of the four groups: Treg through ICOS and GITR in GIST, M0 macrophages in all four sarcoma subtypes, OX40 in SS, CD40 in GIST and SS. The immune landscape of sarcoma was found to be as heterogeneous as the histotypes and molecular subtypes, but strongly correlated to the histotype. Histotype adapted immunotherapeutic approaches in each sarcoma subtypes must be considered in view of these results, consistently with the already reported specific response of histotypes of ICPs.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:59:39Z