Sex-specific aspects of epidemiology, ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
URL permanente :
Titre :
Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours
Auteur(s) :
Le Rhun, Emilie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Weller, Michael [Auteur]
Universität Zürich [Zürich] = University of Zurich [UZH]
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Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Weller, Michael [Auteur]
Universität Zürich [Zürich] = University of Zurich [UZH]
Titre de la revue :
ESMO Open
Nom court de la revue :
ESMO Open
Numéro :
5
Pagination :
e001034
Éditeur :
BMJ
Date de publication :
2020-11-01
ISSN :
2059-7029
Mot(s)-clé(s) :
glioma
male
female
sex
meningioma
male
female
sex
meningioma
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Recent years have seen a great interest in sex-specific aspects of many diseases, including cancer, in part because of the assumption that females have often not been adequately represented in early drug development and ...
Lire la suite >Recent years have seen a great interest in sex-specific aspects of many diseases, including cancer, in part because of the assumption that females have often not been adequately represented in early drug development and determination of safety, tolerability and efficacy in clinical trials. Brain tumours represent a highly heterogeneous group of neoplastic diseases with strong variation of incidence by age, but partly also by sex. Most gliomas are more common in men whereas meningiomas, the most common primary intracranial tumours, are more common in females. Potential sex-specific genetic risk factors and specific sex biology have been reported in a tumour-specific manner. Several small studies have indicated differences in tolerability and safety of, as well as benefit from, treatment by sex, but no conclusive data have been generated. Exploring sex-specific aspects of neuro-oncology should be studied more systematically and in more depth in order to uncover the biological reasons for known sex differences in this disease.Lire moins >
Lire la suite >Recent years have seen a great interest in sex-specific aspects of many diseases, including cancer, in part because of the assumption that females have often not been adequately represented in early drug development and determination of safety, tolerability and efficacy in clinical trials. Brain tumours represent a highly heterogeneous group of neoplastic diseases with strong variation of incidence by age, but partly also by sex. Most gliomas are more common in men whereas meningiomas, the most common primary intracranial tumours, are more common in females. Potential sex-specific genetic risk factors and specific sex biology have been reported in a tumour-specific manner. Several small studies have indicated differences in tolerability and safety of, as well as benefit from, treatment by sex, but no conclusive data have been generated. Exploring sex-specific aspects of neuro-oncology should be studied more systematically and in more depth in order to uncover the biological reasons for known sex differences in this disease.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
INSERM
Université de Lille
Université de Lille
Collections :
Date de dépôt :
2022-06-15T13:59:52Z
2023-04-12T08:25:53Z
2023-04-12T08:25:53Z
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