Titre :

Metabolomic and metataxonomic fingerprinting of human milk suggests compositional stability over a natural term of breastfeeding to 24 months

Auteur(s) :

Shenker, Natalie S. [Auteur]
Perdones-Montero, Alvaro [Auteur]
Burke, Adam [Auteur]
Stickland, Sarah [Auteur]
Mcdonald, Julie A. K. [Auteur]
Alexander-Hardiman, Kate [Auteur]
Flanagan, James [Auteur]
Takats, Zoltan [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Cameron, Simon J. S. [Auteur]

Titre de la revue :

Nutrients

Nom court de la revue :

Nutrients

Numéro :

12

Pagination :

-

Date de publication :

2020-11-01

Mot(s)-clé(s) :

metabolomic fingerprinting
human milk
metataxonomics

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in collaboration with the 'Parenting Science Gang' citizen science ...
Lire la suite >Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in collaboration with the 'Parenting Science Gang' citizen science group evaluated the metabolite and bacterial composition of human milk from 62 participants (infants aged 3-48 months), nearly 3 years longer than previous studies. We utilised rapid evaporative ionisation mass spectrometry (REIMS) for metabolic fingerprinting and 16S rRNA gene metataxonomics for microbiome composition analysis. Milk expression volumes were significantly lower beyond 24 months of lactation, but there were no corresponding changes in bacterial load, composition, or whole-scale metabolomic fingerprint. Some individual metabolite features (~14%) showed altered abundances in nursling age groups above 24 months. Neither milk expression method nor nursling sex affected metabolite and metataxonomic fingerprints. Self-reported lifestyle factors, including diet and physical traits, had minimal impact on metabolite and metataxonomic fingerprints. Our findings suggest remarkable consistency in human milk composition over natural-term lactation. The results add to previous studies suggesting that milk donation can continue up to 24 months postnatally. Future longitudinal studies will confirm the inter-individual and temporal nature of compositional variations and the use of donor milk as a personalised therapeutic.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Date de dépôt :

2022-06-15T13:59:57Z