Titre :

The nanotumor consortium - towards the tumor cell atlas

Auteur(s) :

Colin, Florent [Auteur]
Schauer, Kristine [Auteur]
Hamiche, Ali [Auteur]
Martineau, Pierre [Auteur]
Borg, Jean-Paul [Auteur]
Bednar, Jan [Auteur]
Bertolin, Guilia [Auteur]
Camoin, Luc [Auteur]
Collette, Yves [Auteur]
Dimitrov, Stephan [Auteur]
FOURNIER, Isabelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Hyenne, Vincent [Auteur]
Mendoza-Parra, Marco A. [Auteur]
Morelli, Xavier [Auteur]
Ronde, Philippe [Auteur]
Sumara, Izabela [Auteur]
Tramier, Marc [Auteur]
Schultz, Patrick [Auteur]
Goetz, Jacky G. [Auteur]

Titre de la revue :

Biology of the cell

Nom court de la revue :

Biol Cell

Date de publication :

2021-02-07

ISSN :

1768-322X

Mot(s)-clé(s) :

Cellular Imaging
Cancer
Metastasis
Oncology
Electron & Light Microscopy

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Cancer is a multi-step disease where an initial tumour progresses through critical steps shaping, in most cases, life-threatening secondary foci called metastases. The oncogenic cascade involves genetic, epigenetic, ...
Lire la suite >Cancer is a multi-step disease where an initial tumour progresses through critical steps shaping, in most cases, life-threatening secondary foci called metastases. The oncogenic cascade involves genetic, epigenetic, signalling pathways, intracellular trafficking and/or metabolic alterations within cancer cells. In addition, pre-malignant and malignant cells orchestrate complex and dynamic interactions with non-malignant cells and acellular matricial components or secreted factors within the tumour microenvironment that is instrumental in the progression of the disease. As our aptitude to effectively treat cancer mostly depends on our ability to decipher, properly diagnose and impede cancer progression and metastasis formation, full characterisation of molecular complexes and cellular processes at play along the metastasis cascade is crucial. For many years, the scientific community lacked adapted imaging and molecular technologies to accurately dissect, at the highest resolution possible, tumour and stromal cells behaviour within their natural microenvironment. In that context, the NANOTUMOR consortium is a French national multi-disciplinary workforce which aims at a providing a multi-scale characterisation of the oncogenic cascade, from the atomic level to the dynamic organisation of the cell in response to genetic mutations, environmental changes or epigenetic modifications. Ultimately, this program aims at identifying new therapeutic targets using innovative drug design.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Date de dépôt :

2022-06-15T14:00:04Z