Title :

A novel bio-inspired hydrogel-based lattice structure to mechanically mimic human annulus fibrosus: a finite element study

Author(s) :

Kandil, Karim [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Kaoua, Sid Ali [Auteur]
Mesbah, Amar [Auteur]
Voznyak, Yuri [Auteur]
Zairi, Fahmi [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Zairi, Fahed [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]

Journal title :

International Journal of Mechanical Sciences

Abbreviated title :

Int. J. Mech. Sci.

Volume number :

211

Pages :

106775

Publisher :

Elsevier

Publication date :

2021-12-01

ISSN :

0020-7403

Keyword(s) :

Artificial annulus fibrosus
Transversal behavior
Regional dependence
Lattice structure
Hydrogel

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Intervertebral disc hernia and dysfunctions are the most common health problems that affect humans. For this reason, the need of disc prosthetics, and especially annulus fibrosus replacements, is becoming increasingly ...
Show more >Intervertebral disc hernia and dysfunctions are the most common health problems that affect humans. For this reason, the need of disc prosthetics, and especially annulus fibrosus replacements, is becoming increasingly mandatory and urgent. In the present paper, we present a novel bio-inspired hydrogel-based replacement system with rational mechanically mimetic designs of human annulus fibrosus. The new system consists of hydrogel-based lattice structure with octagonal cells separated by polylactide fibers reinforced hydrogel-based sheets. The mechanics of the new designs may be rationally controlled by tailoring microstructure, in terms of polylactide fibers orientation and hydrogel intrinsic viscosity, and mesostructure in terms of cell walls/sheets thickness. The new designs are successfully compared to the natural annulus fibrosus mechanics in terms of nonlinear stiffness and transversal behavior while considering regional dependency. The impressive biomimetic capabilities of the proposed hydrogel-based lattice structure allow foreseeing the possibility of designing personalized disc prosthetics by advanced 3D printing technologies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

IMT Lille Douai
INSERM
Institut Catholique Lille
Univ. Artois
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T14:00:28Z
2025-04-02T10:00:37Z