Titre :

Migration collective cellulaire sur des substrats courbes cylindriques

Auteur(s) :

Glentis, Alexandros [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Blanch-Mercader, Carles [Auteur]
Laboratoire Physico-Chimie Curie [Institut Curie] [PCC]
Balasubramaniam, Lakshmi [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Saw, Thuan Beng [Auteur]
Mechanobiology Institute [Singapore] [MBI]
D’alessandro, Joseph [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Janel, Sebastien [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Douanier, Audrey [Auteur]
Centre de recherche en Biologie cellulaire de Montpellier [CRBM]
Delaval, Benedicte [Auteur]
Centre de recherche en Biologie cellulaire de Montpellier [CRBM]
Lafont, Frank [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Lim, Chwee Teck [Auteur]
National University of Singapore [NUS]
Mechanobiology Institute [Singapore] [MBI]
Delacour, Delphine [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Prost, Jacques [Auteur]
Mechanobiology Institute [Singapore] [MBI]
Laboratoire Physico-Chimie Curie [Institut Curie] [PCC]
Xi, Wang [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Ladoux, Benoit [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]

Titre de la revue :

Science Advances

Pagination :

365

Éditeur :

American Association for the Advancement of Science (AAAS)

Date de publication :

2022-09-16

ISSN :

2375-2548

Discipline(s) HAL :

Physique [physics]
Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship ...
Lire la suite >Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous active matter processes and to vital morphogenetic and embryonic processes. Here, using interdisciplinary approaches, we study the dynamics of epithelial layers lining different cylindrical surfaces. We observe large-scale, persistent, and circumferential rotation in both concavely and convexly curved cylindrical tissues. While epithelia of inverse curvature show an orthogonal switch in actomyosin network orientation and opposite apicobasal polarities, their rotational movements emerge and vary similarly within a common curvature window. We further reveal that this persisting rotation requires stable cell-cell adhesion and Rac-1–dependent cell polarity. Using an active polar gel model, we unveil the different relationships of collective cell polarity and actin alignment with curvatures, which lead to coordinated rotational behavior despite the inverted curvature and cytoskeleton order.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL