Title :

The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

Author(s) :

Glentis, Alexandros [Auteur]
Blanch-Mercader, Carles [Auteur]
Laboratoire Physico-Chimie Curie [Institut Curie] [PCC]
Balasubramaniam, Lakshmi [Auteur]
Saw, Thuan Beng [Auteur]
Mechanobiology Institute [Singapore] [MBI]
D’alessandro, Joseph [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Janel, Sebastien [Auteur]
Douanier, Audrey [Auteur]
Centre de recherche en Biologie cellulaire de Montpellier [CRBM]
Delaval, Benedicte [Auteur]
Centre de recherche en Biologie cellulaire de Montpellier [CRBM]
Lafont, Frank [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Lim, Chwee Teck [Auteur]
Mechanobiology Institute [Singapore] [MBI]
Delacour, Delphine [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Prost, Jacques [Auteur]
Mechanobiology Institute [Singapore] [MBI]
Laboratoire Physico-Chimie Curie [Institut Curie] [PCC]
Xi, Wang [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]
Ladoux, Benoit [Auteur]
Institut Jacques Monod [IJM (UMR_7592)]

Journal title :

Science Advances

Publisher :

American Association for the Advancement of Science (AAAS)

Publication date :

2022-09-16

ISSN :

2375-2548

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship ...
Show more >Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous active matter processes and to vital morphogenetic and embryonic processes. Here, using interdisciplinary approaches, we study the dynamics of epithelial layers lining different cylindrical surfaces. We observe large-scale, persistent, and circumferential rotation in both concavely and convexly curved cylindrical tissues. While epithelia of inverse curvature show an orthogonal switch in actomyosin network orientation and opposite apicobasal polarities, their rotational movements emerge and vary similarly within a common curvature window. We further reveal that this persisting rotation requires stable cell-cell adhesion and Rac-1–dependent cell polarity. Using an active polar gel model, we unveil the different relationships of collective cell polarity and actin alignment with curvatures, which lead to coordinated rotational behavior despite the inverted curvature and cytoskeleton order.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Submission date :

2022-11-17T03:50:16Z