Title :

Prognostic significance of reverse dipping status on lower limb event in type 2 diabetic patients without peripheral arterial disease.

Author(s) :

Delsart, Pascal [Auteur]
Institut Coeur Poumon [CHU Lille]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Lemaitre, Madleen [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Vanbergue, Anne [Auteur]
Génomique Intégrative et Modélisation des Maladies Métaboliques (EGID) - UMR 8199
Ninni, Sandro [Auteur]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Bauters, Christophe [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Ledieu, Guillaume [Auteur]
Eymard, Diane-Flore [Auteur]
Baudoux, Florence [Auteur]
Le Chevalier De Preville, Agathe [Auteur]
Sobocinski, Jonathan [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Montaigne, David [Auteur]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
Mounier-Vehier, Claire [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Institut Coeur Poumon [CHU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

Acta Diabetologica

Volume number :

59

Pages :

843–850

Publisher :

Springer Verlag

Publication date :

2022-03-27

ISSN :

1432-5233

Keyword(s) :

Nocturnal dipping
Lower limb revascularization
Lower limb amputation disease
Type 2 diabetes mellitus
Ambulatory blood pressure monitoring

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Aims We assessed reverse dipping influence on the risk of lower limb events in type 2 diabetic patients without peripheral arterial disease. Methods Patients with type 2 diabetes addressed for cardiovascular risk ...
Show more >Aims We assessed reverse dipping influence on the risk of lower limb events in type 2 diabetic patients without peripheral arterial disease. Methods Patients with type 2 diabetes addressed for cardiovascular risk stratification in our university hospital from 2008 to 2012 underwent 24 h blood pressure monitoring. Patients with a prior history of limb revascularization or with a stenosis > 50% of the legs were excluded. Reverse dipping was defined as a greater night-versus day-time systolic blood pressure. The endpoint was the first occurrence of lower limb revascularization or limb amputation. Hazard ratios (HRs) and 95% confidence intervals were calculated using the Cox model. Results Two hundred and eighty-one patients were included. During a median follow-up of 9.4 [7.7–10.6] years, 20 lower limb events and 45 all-cause deaths were observed. Thirty-five patients were reverse dippers. The reverse dipping status was associated with lower limb events when considering all-cause death as a competitive risk, (HR 3.61 [1.16–11.2], P = 0.026). Reverse dipping, HbA1C and proteinuria were independently associated with lower limb outcome in a multivariable analysis (respectively HR 4.09 [1.29–12.9], P = 0.017, HR 1.30 [1.04–1.63], P = 0.022 and HR 1.06 [1.02–1.11], P = 0.001). Conclusions Reverse dipping status is independently associated with worse limb outcome in type 2 diabetic patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Submission date :

2022-12-08T01:16:20Z
2023-02-15T12:54:43Z
2023-11-30T13:06:38Z
2023-12-13T10:48:25Z