Title :

Dynamic Disorder in a Nano-Sized Channel-Shaped Pharmaceutical Cocrystal Architecture

Author(s) :

T. Correia, Natália [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Roca Paixao, Luisa-Viviane [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Danede, Florence [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Viciosa, Maria T. [Auteur]

Morritt, Alexander Lee [Auteur]
University of East Anglia [Norwich] [UEA]
Khimyak, Yaroslav Z. [Auteur]
University of East Anglia [Norwich] [UEA]
Affouard, Frédéric [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Conference title :

11th Conference on Broadband Dielectric Spectroscopy and its applications

City :

San Sebastian

Country :

Espagne

Start date of the conference :

2022-09-04

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

Cocrystals are molecular solids that are neutral crystalline single-phase materials composed of two or more different molecular compounds associated via weak supramolecular interactions such as van der Waals, hydrogen, ...
Show more >Cocrystals are molecular solids that are neutral crystalline single-phase materials composed of two or more different molecular compounds associated via weak supramolecular interactions such as van der Waals, hydrogen, halogen or π-π stacking. Cocrystals have shown a considerable increase of interest in recent years due to their possibility to improve many properties of pharmaceuticals (API) such as aqueous solubility, dissolution rate, hygroscopicity bioavailability, or mechanical properties. In this work, we aim to demonstrate that cocrystals may offer a new type of interesting confinement environments including the possibilitty to investigate rotational and translational dynamics in a true nanometric size channel-like architecture. Some results will be presented based on complementary Broadband Dielectric Spectroscopy, Powder X-ray Diffraction and 1H-13C CP/MAS solid-state NMR experiments combined with Molecular Dynamics simulations.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2023-01-29T09:41:07Z
2023-02-02T13:57:41Z