Title :

Is airway damage during physical exercise related to airway dehydration? Inputs from a computational model.

Author(s) :

Karamaoun, Cyril [Auteur]
Laboratoire Jean Alexandre Dieudonné [LJAD]
Haut, Benoît [Auteur]
Advanced Technologies in Information Processing Systems [ATIPS Labs]
Blain, Gregory [Auteur]
LAMHESS - E1 Performance Sportive : Optimisation de la performance de haut niveau
Bernard, Alfred [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Daussin, Frédéric [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Dekerle, Jeanne [Auteur]
University of Brighton
Bougault, Valerie [Auteur]
Laboratoire Motricité Humaine Expertise Sport Santé [LAMHESS]
Mauroy, Benjamin [Auteur]
Laboratoire Jean Alexandre Dieudonné [LJAD]

Journal title :

Journal of Applied Physiology

Abbreviated title :

J Appl Physiol (1985)

Volume number :

132

Pages :

1031-1040

Publication date :

2022-02-25

ISSN :

1522-1601

Keyword(s) :

airway dehydration threshold
computational modeling
exercise ventilation
healthy participants
serum cc16

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In healthy subjects, at low minute ventilation (V_ E) during physical exercise, the water content and temperature of the airways are well regulated. However, with the increase in V_ E, the bronchial mucosa becomes dehydrated ...
Show more >In healthy subjects, at low minute ventilation (V_ E) during physical exercise, the water content and temperature of the airways are well regulated. However, with the increase in V_ E, the bronchial mucosa becomes dehydrated and epithelial damage occurs. Our goal was to demonstrate the correspondence between the ventilatory threshold inducing epithelial damage, measured experimentally, and the dehydration threshold, estimated numerically. In 16 healthy adults, we assessed epithelial damage before and following a 30-min continuous cycling exercise at 70% of maximal work rate, by measuring the variation pre- to postexercise of serum club cell protein (cc16/cr). Blood samples were collected at rest, just at the end of the standardized 10 min warm-up, and immediately, 30 min and 60 min postexercise. Mean V_ E during exercise was kept for analysis. Airway water and heat losses were estimated using a computational model adapted to the experimental conditions and were compared with a literature-based threshold of bronchial dehydration. Eleven participants exceeded the threshold for bronchial dehydration during exercise (group A) and five did not (group B). Compared with post warm-up, the increase in cc16/cr postexercise was significant (mean increase ± SE: 0.48 ± 0.08 ng·L 1 only in group A but not in group B (mean difference ± SE: 0.10 ± 0.04 ng·L 1). This corresponds to an increase of 101 ± 32% [range: 16%–367%] in group A (mean ± SE). Our findings suggest that the use of a computational model may be helpful to estimate an individual dehydration threshold of the airways that is associated with epithelial damage during physical exercise.Show less >

Language :

Anglais

Audience :

Internationale

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Submission date :

2023-05-16T06:41:43Z
2023-05-31T12:14:45Z
2023-06-21T07:00:53Z