Long-term physicochemical stability of ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags.
Author(s) :
Closset, M. [Auteur]
CHU UCL Namur
Onorati, S. [Auteur]
CHU UCL Namur
Colsoul, M. L. [Auteur]
CHU UCL Namur
Goderniaux, N. [Auteur]
CHU UCL Namur
Bihin, B. [Auteur]
CHU UCL Namur
Jamart, J. [Auteur]
CHU UCL Namur
Soumoy, L. [Auteur]
CHU UCL Namur
Hecq, J. D. [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, L. [Auteur]
CHU UCL Namur
CHU UCL Namur
Onorati, S. [Auteur]
CHU UCL Namur
Colsoul, M. L. [Auteur]
CHU UCL Namur
Goderniaux, N. [Auteur]
CHU UCL Namur
Bihin, B. [Auteur]
CHU UCL Namur
Jamart, J. [Auteur]
CHU UCL Namur
Soumoy, L. [Auteur]
CHU UCL Namur
Hecq, J. D. [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, L. [Auteur]
CHU UCL Namur
Journal title :
Journal of Oncology Pharmacy Practice
Abbreviated title :
J Oncol Pharm Pract
Pages :
10781552231152618
Publisher :
SAGE Publications
Publication date :
2023-02-28
ISSN :
1477-092X
Keyword(s) :
Stability
dose banding
5-fluorouracil
chromatography
dose banding
5-fluorouracil
chromatography
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized ...
Show more >Background Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized Intravenous Admixture Service. Aim of the study To evaluate the long-term stability of 5-fluorouracil at banded doses (700 mg and 800 mg) in polyolefin bags. Materials and methods Ten polyolefin bags were prepared under aseptic conditions and stored at 23 ± 2°C for 24 days. Five of them were composed of 14 mL 5-fluorocuracil (700 g) in 100 mL 0.9% sodium chloride solution and the five other of 16 mL 5-fluorouracil (800 mg) in 100 mL 0.9% sodium chloride solution. At defined times, physical stability parameters were assessed: optical densities, pH measurements, visual and microscopical inspections. Solutions concentrations were measured using high-performance liquid chromatography coupled with a photodiode array detector. Results No change was observed on pH and optical density measurements during the study period. Visual and microscopical inspections remained free of colour change, precipitate, microagregate or crystal. The concentrations of 5-Fluorouracil in 800 mg bags remained stable for 24 days while the concentration in 700 mg bags showed a stability of at least 17 days. Conclusion Five-fluorouracil at banded doses of 700 and 800 mg in polyolefin bags is physicochemically stable for at least 17 days at 23 ± 2°C. These results support the possibility of in advance centralised preparation.Show less >
Show more >Background Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized Intravenous Admixture Service. Aim of the study To evaluate the long-term stability of 5-fluorouracil at banded doses (700 mg and 800 mg) in polyolefin bags. Materials and methods Ten polyolefin bags were prepared under aseptic conditions and stored at 23 ± 2°C for 24 days. Five of them were composed of 14 mL 5-fluorocuracil (700 g) in 100 mL 0.9% sodium chloride solution and the five other of 16 mL 5-fluorouracil (800 mg) in 100 mL 0.9% sodium chloride solution. At defined times, physical stability parameters were assessed: optical densities, pH measurements, visual and microscopical inspections. Solutions concentrations were measured using high-performance liquid chromatography coupled with a photodiode array detector. Results No change was observed on pH and optical density measurements during the study period. Visual and microscopical inspections remained free of colour change, precipitate, microagregate or crystal. The concentrations of 5-Fluorouracil in 800 mg bags remained stable for 24 days while the concentration in 700 mg bags showed a stability of at least 17 days. Conclusion Five-fluorouracil at banded doses of 700 and 800 mg in polyolefin bags is physicochemically stable for at least 17 days at 23 ± 2°C. These results support the possibility of in advance centralised preparation.Show less >
Language :
Anglais
Audience :
Internationale
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2023-05-25T02:17:45Z
2023-06-28T11:14:55Z
2023-06-28T11:14:55Z