Title :

Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate

Author(s) :

Kederienė, Vilija [Auteur]
Kaunas University of Technology [KTU]
Jaglinskaitė, Indrė [Auteur]
Kaunas University of Technology [KTU]
Voznikaitė, Paulina [Auteur]
Kaunas University of Technology [KTU]
Rousseau, Jolanta [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Rollin, Patrick [Auteur]
Institut de Chimie Organique et Analytique [ICOA]
Šačkus, Algirdas [Auteur]
Kaunas University of Technology [KTU]
Tatibouët, Arnaud [Auteur]
Institut de Chimie Organique et Analytique [ICOA]

Journal title :

Molecules

Volume number :

26

Pages :

6822

Publisher :

MDPI

Publication date :

2021-11-11

ISSN :

1420-3049

English keyword(s) :

aryl iodides
N-arylation
l-proline
copper catalysis
benzo[b]thiophene

HAL domain(s) :

Chimie/Catalyse

English abstract : [en]

Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon–nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of ...
Show more >Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon–nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides using CuI, l-proline and Cs2CO3 in dioxane at moderate temperature is described. The procedure is an extremely general, relatively cheap, and experimentally simple way to afford the N-substituted products in moderate to high yields. The structures of the new heterocyclic compounds were confirmed by NMR spectroscopy and HRMS investigation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

Catalyse et chimie supramoléculaire (CASU)

Submission date :

2023-05-30T15:26:12Z
2023-06-21T11:36:52Z