Title :

Supramolecular assistance between cyclodextrins and didecyldimethylammonium chloride against enveloped viruses: Toward eco-biocidal formulations

Author(s) :

Leclercq, Loïc [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Dewilde, A. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Aubry, Jean-Marie [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Nardello-Rataj, Véronique [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]

Journal title :

International Journal of Pharmaceutics

Volume number :

512

Pages :

273-281

Publication date :

2016-09-04

ISSN :

0378-5173

Keyword(s) :

Di-n-decyldimethylammonium chloride
Cyclodextrins
Host-Guest chemistry
Lipids extraction
Virus inactivation
Synergistic formulation
Eco-biocide

English abstract : [en]

Nosocomial infections have emerged as important causes of morbidity and mortality in immunocompromised individuals. In this respect, biocides are widely used in hospitals leading to resistant microorganisms. We show here ...
Show more >Nosocomial infections have emerged as important causes of morbidity and mortality in immunocompromised individuals. In this respect, biocides are widely used in hospitals leading to resistant microorganisms. We show here that cyclodextrins can remarkably boost the virucidal activity of di-n-decyldimethylammonium chloride. These oligosaccharides synergistically work with the biocide affording a noticeable reduction of the active virucide concentration between 40 and 85%. Partial replacement of a significant amount of the biocide by eco- and bio-compatible cyclodextrins whilst maintaining the same activity is of great interest as it allows the reduction of the toxicological drawbacks of classical biocide mixtures.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Submission date :

2023-05-30T16:21:38Z
2024-04-19T08:18:16Z