Titre :

The Gonadotropin-Releasing Hormone Associated Peptide Reduces Calcium Entry in Prolactin-Secreting Cells*

Auteur(s) :

Vacher, P. [Auteur]
Seeburg, P.H. [Auteur]
Mariot, Pascal [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Dufy-Barbe, L. [Auteur]
Nikolics, K. [Auteur]
Kerdelhue, B. [Auteur]
Laboratoire de neurobiologie de la reproduction
Dufy, B. [Auteur]
Physiologie et physiopathologie de la signalisation cellulaire [PPSC]

Titre de la revue :

Endocrinology

Pagination :

285-294

Éditeur :

Endocrine Society

Date de publication :

1991-01

ISSN :

0013-7227

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three ...
Lire la suite >The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three different types of PRL-secreting cells: 1) the rat tumor cell line GH3, 2) normal rat pituitary cells in primary culture, and 3) human PRL-secreting adenoma cells. Using different but complementary techniques we show that GAP reduces intracellular Ca++ levels, [Ca++]i, and inhibits Ca++ transients in these cells. This reduction of [Ca++]i results from coordinate actions of GAP on K+ and Ca++ conductances and may explain the inhibitory effect of GAP on hormonal secretion by PRL-secreting cells.Lire moins >

Langue :

Anglais

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL

Date de dépôt :

2023-09-21T09:28:33Z