Club Cell TRPV4 Serves as a Damage Sensor ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Auteur(s) :
Wiesner, Darin L [Auteur]
Merkhofer, Richard M [Auteur]
Ober, Carole [Auteur]
Kujoth, Gregory C [Auteur]
Niu, Mengyao [Auteur]
Keller, Nancy P [Auteur]
Gern, James E [Auteur]
Brockman-Schneider, Rebecca A [Auteur]
Evans, Michael D [Auteur]
Jackson, Daniel J [Auteur]
Warner, Thomas [Auteur]
Jarjour, Nizar N [Auteur]
Esnault, Stephane J [Auteur]
Feldman, Michael B [Auteur]
Freeman, Matthew [Auteur]
Mou, Hongmei [Auteur]
Vyas, Jatin M [Auteur]
Klein, Bruce S [Auteur]
Merkhofer, Richard M [Auteur]
Ober, Carole [Auteur]
Kujoth, Gregory C [Auteur]
Niu, Mengyao [Auteur]
Keller, Nancy P [Auteur]
Gern, James E [Auteur]
Brockman-Schneider, Rebecca A [Auteur]
Evans, Michael D [Auteur]
Jackson, Daniel J [Auteur]
Warner, Thomas [Auteur]
Jarjour, Nizar N [Auteur]
Esnault, Stephane J [Auteur]
Feldman, Michael B [Auteur]
Freeman, Matthew [Auteur]
Mou, Hongmei [Auteur]
Vyas, Jatin M [Auteur]
Klein, Bruce S [Auteur]
Titre de la revue :
Cell Host & Microbe
Nom court de la revue :
Cell Host Microbe
Numéro :
27
Pagination :
614-628.e6
Date de publication :
2020-04-08
ISSN :
1934-6069
Mot(s)-clé(s) en anglais :
Allergens
Animals
Aspergillus fumigatus
Asthma
Bronchioles
Calcineurin
Calcium Channels
Calcium Signaling
Cohort Studies
Eosinophilia
Epithelial Cells
Humans
Inflammation
Mice
Mice, Inbred C57BL
Serine Endopeptidases
T-Lymphocytes
TRPV Cation Channels
Aspergillus
TRPV4
alkaline protease 1
asthma
calcineurin
calcium
club cells
Animals
Aspergillus fumigatus
Asthma
Bronchioles
Calcineurin
Calcium Channels
Calcium Signaling
Cohort Studies
Eosinophilia
Epithelial Cells
Humans
Inflammation
Mice
Mice, Inbred C57BL
Serine Endopeptidases
T-Lymphocytes
TRPV Cation Channels
Aspergillus
TRPV4
alkaline protease 1
asthma
calcineurin
calcium
club cells
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Airway epithelium is the first body surface to contact inhaled irritants and report danger. Here, we report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because ...
Lire la suite >Airway epithelium is the first body surface to contact inhaled irritants and report danger. Here, we report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because proteases are critical components of many allergens that provoke asthma. In a murine model, Alp1 elicits helper T (Th) cell-dependent lung eosinophilia that is initiated by the rapid response of bronchiolar club cells to Alp1. Alp1 damages bronchiolar cell junctions, which triggers a calcium flux signaled through calcineurin within club cells of the bronchioles, inciting inflammation. In two human cohorts, we link fungal sensitization and/or asthma with SNP/protein expression of the mechanosensitive calcium channel, TRPV4. TRPV4 is also necessary and sufficient for club cells to sensitize mice to Alp1. Thus, club cells detect junction damage as mechanical stress, which signals danger via TRPV4, calcium, and calcineurin to initiate allergic sensitization.Lire moins >
Lire la suite >Airway epithelium is the first body surface to contact inhaled irritants and report danger. Here, we report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because proteases are critical components of many allergens that provoke asthma. In a murine model, Alp1 elicits helper T (Th) cell-dependent lung eosinophilia that is initiated by the rapid response of bronchiolar club cells to Alp1. Alp1 damages bronchiolar cell junctions, which triggers a calcium flux signaled through calcineurin within club cells of the bronchioles, inciting inflammation. In two human cohorts, we link fungal sensitization and/or asthma with SNP/protein expression of the mechanosensitive calcium channel, TRPV4. TRPV4 is also necessary and sufficient for club cells to sensitize mice to Alp1. Thus, club cells detect junction damage as mechanical stress, which signals danger via TRPV4, calcium, and calcineurin to initiate allergic sensitization.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2023-10-21T11:43:47Z
Fichiers
- Club Cell TRPV4 .pdf
- Version éditeur
- Accès restreint
- Accéder au document