Title :

Amphiphilic Block Copolymers Based on PEG and UV-Triggerable Self-Immolative Polymers

Author(s) :

Joó, Adám Viktor [Collaborateur]
1002334|||Unité Matériaux et Transformations - UMR 8207 [UMET]
Potier, Jonathan [Collaborateur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Ouhssou, Nouzha [Collaborateur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Pepino Mendes, Bárbara [Collaborateur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Le Fer, Gaëlle [Collaborateur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Collaborateur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Belkhir, Kedafi [Auteur correspondant]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

ACS Applied Polymer Materials

Abbreviated title :

ACS Appl. Polym. Mater.

Volume number :

5

Pages :

8960-8971

Publisher :

American Chemical Society (ACS)

Publication date :

2023-10-13

ISSN :

2637-6105

English keyword(s) :

triggered depolymerization
self-immolative polymers
UV-responsive polymers
self-assemblies

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères

English abstract : [en]

Self-immolative polymers (SIPs) allow a triggered depolymerization, which is an effective way to control the function of polymer-based systems. In this work, hydrophobic SIP segments and hydrophilic polyethylene glycol ...
Show more >Self-immolative polymers (SIPs) allow a triggered depolymerization, which is an effective way to control the function of polymer-based systems. In this work, hydrophobic SIP segments and hydrophilic polyethylene glycol (PEG) are combined in diblock and triblock amphiphilic architectures, and the SIP-based blocks are made of polycaprolactone-like backbones with UV-sensitive nitrobenzene pendant groups. The depolymerization of the designed architectures in solution is monitored by NMR, UV–vis spectroscopy, and size exclusion chromatography, showing complete cleavage of the triggering units in the SIP parts after about 25 min under UV irradiation and depolymerization rates of the SIP backbones up to 60%. Self-assemblies are prepared from the diblock copolymers, their stability is verified by DLS, and the UV-triggered disintegration of the self-assemblies is demonstrated by SEM, Tindall effect, and by monitoring the derived count rate in DLS, showing a rapid disintegration (after 2 to 6 min under UV light). These SIP-based structures allow a fast, controlled, and on-demand disintegration of self-assemblies, with the ability to encapsulate and release on-demand the Nile red as a hydrophobic model molecule.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2023-11-11T12:17:16Z
2023-11-13T19:27:55Z
2023-11-15T15:05:25Z