Title :

Shift in Clinical Profile of Hospitalized Pneumonia in Children in the Non-pharmaceutical Interventions Period During the COVID-19 Pandemic: A Prospective Multicenter Study.

Author(s) :

Rybak, Alexis [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Ouldali, Naïm [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Angoulvant, François [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Minodier, Philippe [Auteur]
Hôpital Nord [CHU - APHM]
Biscardi, Sandra [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Madhi, Fouad [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Hau, Isabelle [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Santos, Audrey [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Martinot, Alain [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Dommergues, Marie-Aliette [Auteur]
Centre Hospitalier de Versailles André Mignot [CHV]
Gras-Le Guen, Christèle [Auteur]
Launay, Elise [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Levieux, Karine [Auteur]
Zenkhri, Ferielle [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Craiu, Irina [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Lorrot, Mathie [Auteur]
CHU Trousseau [APHP]
Gillet, Yves [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Mezgueldi, Ellia [Auteur]
Hospices Civils de Lyon [HCL]
Faye, Albert [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
Béchet, Stéphane [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Varon, Emmanuelle [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Cohen, Robert [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Levy, Corinne [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]

Journal title :

Frontiers in Pediatrics

Abbreviated title :

Front Pediatr

Volume number :

10

Pages :

782894

Publication date :

2022-04-17

ISSN :

2296-2360

English keyword(s) :

community-acquired pneumonia
COVID-19
children
non-pharmaceutical intervention
time series analysis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Non-pharmaceutical interventions (NPIs) against coronavirus disease 2019 were implemented in March 2020. These measures were followed by a major impact on viral and non-viral diseases. We aimed to assess the impact of NPI ...
Show more >Non-pharmaceutical interventions (NPIs) against coronavirus disease 2019 were implemented in March 2020. These measures were followed by a major impact on viral and non-viral diseases. We aimed to assess the impact of NPI implementation in France on hospitalized community-acquired pneumonia (hCAP) frequency and the clinical and biological characteristics of the remaining cases in children. We performed a quasi-experimental interrupted time-series analysis. Between June 2014 and December 2020, eight pediatric emergency departments throughout France reported prospectively all cases of hCAP in children from age 1 month to 15 years. We estimated the impact on the monthly number of hCAP using segmented linear regression with autoregressive error model. We included 2,972 hCAP cases; 115 occurred during the NPI implementation period. We observed a sharp decrease in the monthly number of hCAP after NPI implementation [−63.0% (95 confidence interval, −86.8 to −39.2%); p < 0.001]. Children with hCAP were significantly older during than before the NPI period (median age, 3.9 vs. 2.3 years; p < 0.0001), and we observed a higher proportion of low inflammatory marker status (43.5 vs. 33.1%; p = 0.02). Furthermore, we observed a trend with a decrease in the proportion of cases with pleural effusion (5.3% during the NPI period vs. 10.9% before the NPI; p = 0.06). NPI implementation during the COVID-19 (coronavirus disease 2019) pandemic led not only to a strong decrease in the number of hCAP cases but also a modification in the clinical profile of children affected, which may reflect a change in pathogens involved.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T04:20:44Z
2024-05-06T07:22:33Z