Title :

Overall and net survival of patients with sarcoma between 2005 and 2010: Results from the French Network of Cancer Registries (FRANCIM).

Author(s) :

Amadeo, Brice [Auteur]
Bordeaux population health [BPH]
Registre Général des Cancers de la Gironde
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Coindre, Jean-Michel [Auteur]
Institut Bergonié [Bordeaux]
Ray-Coquard, Isabelle [Auteur]
Centre Léon Bérard [Lyon]
Plouvier, Sandrine [Auteur]
Registre général des cancers de Lille et de sa région [GCS-C2RC]
Delafosse, Patricia [Auteur]
Registre des cancers de l’Isère [CHU de Grenoble]
Bouvier, Anne-Marie [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]
Gallet, Justine [Auteur]
Bordeaux population health [BPH]
Lacourt, Aude [Auteur]
Bordeaux population health [BPH]
Galvin, Angéline [Auteur]
Bordeaux population health [BPH]
Coureau, Gaëlle [Auteur]
Bordeaux population health [BPH]
Registre Général des Cancers de la Gironde
Monnereau, Alain [Auteur]
Institut Bergonié [Bordeaux]
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Desandes, Emmanuel [Auteur]
Epidemiology of childhood and adolescent cancer | Epidémiologie des cancers de l'enfant et de l'adolescent [EPICEA [CRESS - U1153 / UMR_A 1125]]
Mathoulin-Pélissier, Simone [Auteur]
CIC Bordeaux

Journal title :

Cancer

Abbreviated title :

Cancer

Volume number :

128

Pages :

2483-2492

Publication date :

2022-04-07

ISSN :

1097-0142

English keyword(s) :

cancer registry
France
French Network of Cancer Registries (FRANCIM network)
sarcoma
survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND Sarcomas are rare, heterogeneous, ubiquitously localized malignancies with many histologic subtypes and genomic patterns. The survival of patients with sarcoma has rarely been described based on this ...
Show more >BACKGROUND Sarcomas are rare, heterogeneous, ubiquitously localized malignancies with many histologic subtypes and genomic patterns. The survival of patients with sarcoma has rarely been described based on this heterogeneity; therefore, the authors' objective was to estimate survival outcomes in patients who had sarcomas using the 2020 version of the World Health Organization classification of soft tissue and bone tumors. METHODS Patients older than 15 years who had incident sarcoma diagnosed between 2005 and 2010 were extracted from 14 French population-based cancer registries covering 18% of the French metropolitan population. Vital status for each patient was actively followed up to June 30, 2013. Net survival (NS) was estimated using the unbiased Pohar-Perme method. RESULTS Overall, 4202 patients were included. NS declined with increasing age at diagnosis. According to topographic groups, large 5-year NS disparities were observed, ranging from 47% among women with gynecologic sarcomas to 89% among patients with skin sarcomas. Patients with soft tissue, bone, and gastrointestinal sarcomas had 5-year NS rates of 53%, 61%, and 70%, respectively. Similar heterogeneity was observed according to histologic subtypes, with 5-year NS ranging from 19% for patients with angiosarcomas to 96% for patients with dermatofibrosarcomas. Patients with sarcoma who displayed missense mutations had a better 5-year NS (74%); those with MDM2-amplified sarcomas had the worst NS (45%). CONCLUSIONS NS rates in patients with sarcoma are presented here for the first time based on the 2020 World Health Organization classification applied to population-based registry data. Large prognostic heterogeneity was observed based on age, topographic and histologic groups, and genomic alteration profiles, constituting a benchmark for future studies and clinical trials.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T04:22:04Z
2024-04-29T15:00:06Z