Opioid effect on the autonomic nervous system in a fetal sheep model

Recher, Morgan; Garabedian, Charles; Aubry, Estelle; Sharma, Dyuti; Madjid, Laura; Storme, Laurent; De Jonckheere, Julien

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00404-020-05917-4

PMID :

33389095

URL permanente :

http://hdl.handle.net/20.500.12210/90458

Titre :

Opioid effect on the autonomic nervous system in a fetal sheep model

Auteur(s) :

Recher, Morgan [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Garabedian, Charles [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Aubry, Estelle [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Sharma, Dyuti [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Madjid, Laura [Auteur]

Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
Storme, Laurent [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
De Jonckheere, Julien [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

Archives of Gynecology and Obstetrics

Nom court de la revue :

Arch Gynecol Obstet

Numéro :

304

Pagination :

p. 73–80

Date de publication :

2021-01

ISSN :

1432-0711

Mot(s)-clé(s) en anglais :

Autonomic nervous system
Fetal heart rate
Fetal sheep
Nalbuphine
Opioid

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose Opioid use during labour can interfere with cardiotocography patterns. Heart rate variability indirectly reflects a fluctuation in the autonomic nervous system and can be monitored through time and spectral ...
Lire la suite >Purpose Opioid use during labour can interfere with cardiotocography patterns. Heart rate variability indirectly reflects a fluctuation in the autonomic nervous system and can be monitored through time and spectral analyses. This experimental study aimed to evaluate the impact of nalbuphine administration on the gasometric, cardiovascular, and autonomic nervous system responses in fetal sheep. Methods This was an experimental study on chronically instrumented sheep fetuses (surgery at 128 ± 2 days of gestational age, term = 145 days). The model was based on a maternal intravenous bolus injection of nalbuphine, a semisynthetic opioid used as an analgesic during delivery. Fetal gasometric parameters (pH, pO2, pCO2, and lactates), hemodynamic parameters (fetal heart rate and mean arterial pressure), and autonomic nervous system tone (short-term and long-term variation, low-frequency domain, high-frequency domain, and fetal stress index) were recorded. Data obtained at 30–60 min after nalbuphine injection were compared to those recorded at baseline. Results Eleven experiments were performed. Fetal heart rate, mean arterial pressure, and activities at low and high frequencies were stable after injection. Short-term variation decreased at T30 min (P = 0.02), and long-term variation decreased at T60 min (P = 0.02). Fetal stress index gradually increased and reached significance at T60 min (P = 0.02). Fetal gasometric parameters and lactate levels remained stable. Conclusion Maternal nalbuphine use during labour may lead to fetal heart changes that are caused by the effect of opioid on the autonomic nervous system; these fluctuations do not reflect acidosis.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T07:25:50Z
2024-03-13T10:39:00Z

Numéro de version	Lien	Date de modification
2	20.500.12210/90458*	2024-03-13T10:35:51Z
1	20.500.12210/90458.1	2023-11-15T07:25:50Z

Opioid effect on the autonomic nervous ...

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Opioid effect on the autonomic nervous ...

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