Title :

Prenatal prediction of postnatal survival in fetuses with congenital diaphragmatic hernia using MRI: lung volume measurement, signal intensity ratio, and effect of experience.

Author(s) :

Dütemeyer, Vivien [Auteur]

Cordier, Anne-Gael [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Cannie, Mieke M. [Auteur]

Bevilacqua, Elisa [Auteur]

Huynh, Van [Auteur]
Hôpital Bicêtre
Debarge, Veronique [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Verpillat, Pauline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Olivier, Camille [Auteur]

Benachi, Alexandra [Auteur]
Service de gynécologie-obstétrique, médecine de la reproduction [Béclère]
Jani, Jacques C. [Auteur]

Journal title :

Journal of Maternal-Fetal & Neonatal Medicine

Abbreviated title :

J. Matern. Fetal. Neonatal. Med.

Volume number :

35

Pages :

1-9

Publication date :

2020-03-28

ISSN :

1476-4954

English keyword(s) :

Congenital diaphragmatic hernia
fetoscopic endoluminal tracheal occlusion
fetal lung signal intensity ratios
magnetic resonance imaging
operator's experience

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To evaluate various signal intensity ratios in isolated congenital diaphragmatic hernia (CDH) and to compare their potential in predicting survival with that of the observed-to-expected (O/E) ratio of total ...
Show more >Objective To evaluate various signal intensity ratios in isolated congenital diaphragmatic hernia (CDH) and to compare their potential in predicting survival with that of the observed-to-expected (O/E) ratio of total fetal lung volume (TFLV) using magnetic resonance imaging (MRI) measurements. Our second objective was to evaluate the impact of operator’s experience in comparing the prediction of postnatal survival by O/E-TFLV. Methods In 75 conservatively managed CDH fetuses and in 50 who underwent fetoscopic endoluminal tracheal occlusion (FETO), the fetal lung-to-amniotic fluid, lung-to-liver, lung-to-muscle, lung-to-spinal fluid signal intensity ratios, respectively LAFSIR, LLSIR, LMSIR, and LSFSIR, were measured, as was O/E-TFLV. Receiver operating characteristic (ROC) curves were constructed and used to compare the various signal intensity ratios with O/E-TFLV in the prediction of postnatal survival. In 72 MRI lung volumes assessed by the referring radiologists in Paris and Lille and secondarily by our expert radiologist in Brussels (M.M.C.) using the same MRI examinations, ROC curves were constructed and used to compare the value of O/E-TFLV determined by the two centers in the prediction of postnatal survival. Results In the total cohort of CDH fetuses, O/E-TFLV and LLSIR were predictive of postnatal survival whereas in the conservatively managed group O/E-TFLV, LLSIR, and LMSIR predicted postnatal survival. O/E-TFLV predicted postnatal survival far better than the signal intensity ratios: area under the ROC curve for prediction by O/E-TFLV in the total cohort was 0.866 (p < .001; standard error = 0.031). The area under the ROC curve for prediction of postnatal survival using O/E-TFLV by MRI evaluated at the referral centers was 0.640 (p = 102; standard error = 0.085), and with O/E-TFLV reevaluated by M.M.C., it was 0.872 (p < .001; standard error = 0.061). Pairwise comparison showed a significant difference between the areas under the ROC curves (difference = 0.187, p = .012; standard error = 0.075). Conclusion In fetuses with CDH with/without FETO, LLSIR was significantly correlated with the prediction of postnatal survival. However, measurement of O/E-TFLV was far better in predicting postnatal outcome. Operator experience in measurement of lung volumes using MRI seem to play a role in the predictive value of the technique.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T09:07:42Z
2023-12-22T08:00:00Z
2024-04-16T07:16:51Z