Title :

Interventions in the management of infection in the foot in diabetes: a systematic review.

Author(s) :

Peters, Edgar J. G. [Auteur]
University of Amsterdam [Amsterdam] = Universiteit van Amsterdam [UvA]
Lipsky, Benjamin A. [Auteur]
University of Washington [Seattle]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Abbas, Zulfiqarali G. [Auteur]
Muhimbili University of Health and Allied Sciences
Aragón-Sánchez, Javier [Auteur]
Université de Las Palmas de Gran Canaria [Espagne] [ULPGC]
Diggle, Mathew [Auteur]
University of Alberta
Embil, John M. [Auteur]
University of Manitoba [Winnipeg]
Kono, Shigeo [Auteur]
Lavery, Lawrence A. [Auteur]
University of Texas Southwestern Medical Center [Dallas]
Malone, Matthew [Auteur]
Western Sydney University
Urbančič-Rovan, Vilma [Auteur]
University Medical Centre Ljubljana [Ljubljana, Slovenia] [UMCL]
Van Asten, Suzanne A. [Auteur]
Leiden University Medical Center [LUMC]

Journal title :

Diabetes/Metabolism Research and Reviews

Abbreviated title :

Diabetes Metab. Res. Rev.

Volume number :

36

Pages :

e3282

Publication date :

2020-03-21

ISSN :

1520-7560

English keyword(s) :

antibiotics
diabetes mellitus
diabetic foot infection
osteomyelitis
surgery
systematic review

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally ...
Show more >The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally produce comparable results, and high-quality data are scarce. In this systematic review, we searched the medical literature using the PubMed and Embase databases for published studies on the treatment of diabetic foot infections as of June 2018. This systematic review is an update of previous reviews, the first of which was undertaken in 2010 and the most recent in 2014, by the infection committee of the International Working Group of the Diabetic Foot. We defined the context of literature by formulating clinical questions of interest, then developing structured clinical questions (PICOs) to address these. We only included data from controlled studies of an intervention to prevent or cure a diabetic foot infection. Two independent reviewers selected articles for inclusion and then assessed their relevant outcomes and the methodological quality. Our literature search identified a total of 15 327 articles, of which we selected 48 for full-text review; we added five more studies discovered by means other than the systematic literature search. Among these selected articles were 11 high-quality studies published in the last 4 years and two Cochrane systematic reviews. Overall, the outcomes in patients treated with the different antibiotic regimens for both skin and soft tissue infection and osteomyelitis of the diabetic foot were broadly equivalent across studies, except that treatment with tigecycline was inferior to ertapenem (±vancomycin). Similar outcomes were also reported in studies comparing primarily surgical and predominantly antibiotic treatment strategies in selected patients with diabetic foot osteomyelitis. There is insufficient high-quality evidence to assess the effect of various adjunctive therapies, such as negative pressure wound therapy, topical ointments or hyperbaric oxygen, on infection related outcomes of the diabetic foot. In general, the quality of more recent trial designs are better in past years, but there is still a great need for further well-designed trials to produce higher quality evidence to underpin our recommendations.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T09:11:50Z
2024-01-09T08:24:11Z