Title :

Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA).

Author(s) :

Patrikidou, Anna [Auteur]
Institut Gustave Roussy [IGR]
Chaigneau, Loic [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Isambert, Nicolas [Auteur]
Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] [UNICANCER/CRLCC-CGFL]
Kitikidou, Kyriaki [Auteur]
Democritus University of Thrace [DUTH]
Shanley, Ryan [Auteur]

Ray-Coquard, Isabelle [Auteur]
Centre Léon Bérard [Lyon]
Valentin, Thibaud [Auteur]
Centre de Recherches en Cancérologie de Toulouse [CRCT]
Malivoir, Bettina [Auteur]
CHU Trousseau [Tours]
Laigre, Maryline [Auteur]

Bay, Jacques-Olivier [Auteur]
CHU Estaing [Clermont-Ferrand]
Moureau-Zabotto, Laurence [Auteur]
Institut Paoli-Calmettes [IPC]
Bompas, Emmanuelle [Auteur]
CRLCC René Gauducheau
Piperno-Neumann, Sophie [Auteur]
Institut Curie [Paris]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Alcindor, Thierry [Auteur]
McGill University = Université McGill [Montréal, Canada]
Guillemet, Cécile [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Duffaud, Florence [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Hügli, Anne [Auteur]
Hôpitaux universitaires de Genève = University Hospitals of Geneva [HUG]
Le Pechoux, Cécile [Auteur]
Institut Gustave Roussy [IGR]
Dhermain, Frédéric [Auteur]
Institut Gustave Roussy [IGR]
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Sperduto, Paul W. [Auteur]

Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]

Journal title :

BMC Cancer

Abbreviated title :

BMC Cancer

Volume number :

20

Pages :

117

Publication date :

2020-02-12

ISSN :

1471-2407

English keyword(s) :

Sarcoma
Brain metastasis
Prognostic index

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Brain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological heterogeneity. Prognostic indices such as the Graded Prognostic Assessment (GPA) index have ...
Show more >Background Brain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological heterogeneity. Prognostic indices such as the Graded Prognostic Assessment (GPA) index have been developed for several primary tumour types presenting with brain metastases (e.g. lung, breast, melanoma), tailored to the specifics of different primary histologies and molecular profiles. Thus far, a prognostic index to direct treatment decisions is lacking for adult sarcoma patients with brain metastases. Methods We performed a multicentre analysis of a national group of expert sarcoma tertiary centres (French Sarcoma Group, GSF-GETO) with the participation of one Canadian and one Swiss centre. The study cohort included adult patients with a diagnosis of a bone or soft tissue sarcoma presenting parenchymal or meningeal brain metastases, managed between January 1992 and March 2012. We assessed the validity of the original GPA index in this patient population and developed a disease-specific Sarcoma-GPA index. Results The original GPA index is not prognostic for sarcoma brain metastasis patients. We have developed a dedicated Sarcoma-GPA index that identifies a sub-group of patients with particularly favourable prognosis based on histology, number of brain lesions and performance status. Conclusions The Sarcoma-GPA index provides a novel tool for sarcoma oncologists to guide clinical decision-making and outcomes research.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T09:23:26Z
2023-12-12T14:10:06Z