Title :

Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana

Author(s) :

Saidi, Nasreddine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blaizot, Romain [Auteur]
Prévot, Ghislaine [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Aoun, Karim [Auteur]
Institut Pasteur de Tunis
Demar, Magalie [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Cazenave, Pierre André [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Bouratbine, Aida [Auteur]
Institut Pasteur de Tunis
Pied, Sylviane [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Frontiers in Immunology

Publisher :

Frontiers

Publication date :

2023-07-27

ISSN :

1664-3224

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance ...
Show more >Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parameters, the evolution of lesions is determined by a complex interaction between parasite factors and the early immune responses triggered, including innate and adaptive mechanisms. Moreover, lesion resolution requires parasite control as well as modulation of the pathologic local inflammation responses and the initiation of wound healing responses. Here, we have summarized recent advances in understanding the in situ immune response to cutaneous leishmaniasis: i ) in North Africa caused by Leishmania (L.) major , L. tropica , and L. infantum , which caused in most cases localized autoresolutives forms, and ii ) in French Guiana resulting from L. guyanensis and L. braziliensis , two of the most prevalent strains that may induce potentially mucosal forms of the disease. This review will allow a better understanding of local immune parameters, including cellular and cytokines release in the lesion, that controls infection and/or protect against the pathogenesis in new world compared to old world CL.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Alliance française contre les maladies parasitaires

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL