Fatal Overdose of Gamma-hydroxybutyrate Acid After Ingestion of 1,4-Butanediol

Le Garff, Erwan; Mesli, Vadim; Cornez, Raphael; Demarly, Christophe; Tournel, Gilles; Hédouin, Valéry

Type de document :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1111/1556-4029.13510

PMID :

28425102

Titre :

Fatal Overdose of Gamma-hydroxybutyrate Acid After Ingestion of 1,4-Butanediol

Auteur(s) :

Le Garff, Erwan [Auteur]

Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Mesli, Vadim [Auteur]

Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Cornez, Raphael [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Demarly, Christophe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tournel, Gilles [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Aliments Bioprocédés Toxicologie Environnements [ABTE]
Hédouin, Valéry [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Titre de la revue :

Journal of Forensic Sciences

Pagination :

326-329

Éditeur :

Wiley

Date de publication :

2018-01

Mot(s)-clé(s) en anglais :

Autopsy
Forensic science
Forensic toxicology
Gamma-hydroxybutyrate acid
Intoxication
Overdose

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

Résumé en anglais : [en]

We report a case of fatal intoxication from 1,4-butanediol (1,4-BD), which was ingested by a young and "naïve" gamma-hydroxybutyrate (GHB) consumer during a party with the co-ingestion of alcohol, cannabis, and ...
Lire la suite >We report a case of fatal intoxication from 1,4-butanediol (1,4-BD), which was ingested by a young and "naïve" gamma-hydroxybutyrate (GHB) consumer during a party with the co-ingestion of alcohol, cannabis, and methylene-dioxy-methamphetamine. The following drug concentrations were found using gas chromatography coupled with mass spectrometry on autopsy samples and on a cup and a glass found at the scene: 20,350 mg/L (bottle) for 1,4-BD; 1020 mg/L (femoral blood), 3380 mg/L (cardiac blood), 47,280 mg/L (gastric content), and 570 mg/L (vitreous humor) for GHB. The concentration of GHB is difficult to interpret in forensic cases due to the possibility of an endogenous production of GHB. The variable tolerance of the user may also modify the peri- and postmortem GHB concentrations. This case underscores the need to have many different sources of toxicology samples analyzed to avoid the hypothesis of endogenous production of GHB.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367

Source :

Harvested from HAL

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