Titre :

Trace elements in e-liquids - Development and validation of an ICP-MS method for the analysis of electronic cigarette refills

Auteur(s) :

Beauval, N. [Auteur]
Howsam, Michael [Auteur]
Centre Universitaire de Mesures et d'Analyses [Université de Lille] [CUMA]
Lille Inflammation Research International Center - U 995 [LIRIC]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Antherieu, S. [Auteur]
Institut Pasteur de Lille
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Allorge, D. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Soyez, M. [Auteur]
Garçon, G. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Goossens, J.F. [Auteur]
Institut de Chimie Pharmaceutique Albert Lespagnol [ICPAL]
Lo-Guidice, J.M. [Auteur]
Garat, A. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]

Titre de la revue :

Regulatory Toxicology and Pharmacology

Éditeur :

Elsevier

Date de publication :

2016

ISSN :

0273-2300

Discipline(s) HAL :

Chimie

Résumé en anglais : [en]

Electronic cigarette use has rapidly increased in recent years. In assessing their safety, and in view of coming regulations, trace elements (TE) are among the potentially toxic compounds required to be evaluated in ...
Lire la suite >Electronic cigarette use has rapidly increased in recent years. In assessing their safety, and in view of coming regulations, trace elements (TE) are among the potentially toxic compounds required to be evaluated in electronic cigarette refill fluids (“e-liquids”). An analytical method using inductively coupled plasma with mass spectrometric detection (ICP-MS) was developed and rigorously validated in order to determine concentrations of 15 TE in 54 e-liquids from a French brand. Despite a significant matrix effect from the main e-liquid constituents, and difficulties related to the current lack of reference materials, our method demonstrated satisfactory linearity, precision and robustness, and permitted the quantification of low concentrations of these 15 elements: lower limits of quantification (LLQ) obtained were ≤4 ppb for all elements except for Ni, Cu and Zn (16 ppb, 20 ppb and 200 ppb, respectively). All TE concentrations in all tested samples were <510 ppb, mostly near or below the LLQs. This method is transposable and is timely for laboratories seeking to meet a prospective demand in light of current or future regulations.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL