Titre :

Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population‐based study

Auteur(s) :

Di Castelnuovo, Augusto [Auteur]
Costanzo, Simona [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Bonaccio, Marialaura [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Mcelduff, Patrick [Auteur]
University of Newcastle [Callaghan, Australia] [UoN]
Hunter Medical Research Institute
Linneberg, Allan [Auteur]
Bispebjerg University Hospital [BUH]
University of Copenhagen = Københavns Universitet [UCPH]
Salomaa, Veikko [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Männistö, Satu [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Moitry, Marie [Auteur]
Université de Strasbourg [UNISTRA]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Ferrières, Jean [Auteur]
Equipe Vieillissement (CERPOP)
Service Cardiologie [CHU Toulouse]
Dallongeville, Jean [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Thorand, Barbara [Auteur]
Helmholtz Zentrum München = German Research Center for Environmental Health [HMGU]
Brenner, Hermann [Auteur]
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] [DKFZ]
Ferrario, Marco [Auteur]
Universitá degli Studi dell’Insubria = University of Insubria [Varese] [Uninsubria]
Veronesi, Giovanni [Auteur]
Universitá degli Studi dell’Insubria = University of Insubria [Varese] [Uninsubria]
Pettenuzzo, Emanuela [Auteur]
Universitá degli Studi dell’Insubria = University of Insubria [Varese] [Uninsubria]
Tamosiunas, Abdonas [Auteur]
Njølstad, Inger [Auteur]
The Arctic University of Norway [Tromsø, Norway] [UiT]
University of Tromsø [UiT]
Drygas, Wojciech [Auteur]
National Institute of Cardiology [Warsaw, Poland] [NIC]
Nikitin, Yuri [Auteur]
Institute of Cytology and Genetics
Söderberg, Stefan [Auteur]
Kee, Frank [Auteur]
Grassi, Guido [Auteur]
Westermann, Dirk [Auteur]
Schrage, Benedikt [Auteur]
Dabboura, Salim [Auteur]
Zeller, Tanja [Auteur]
Kuulasmaa, Kari [Auteur]
Blankenberg, Stefan [Auteur]
Donati, Maria Benedetta [Auteur]
de Gaetano, Giovanni [Auteur]
Iacoviello, Licia [Auteur]

Titre de la revue :

Addiction

Pagination :

312-325

Éditeur :

Wiley

Date de publication :

2022-02

ISSN :

0965-2140

Mot(s)-clé(s) en anglais :

Alcohol intake
HDL cholesterol
cancer mortality
cardiovascular mortality
cohort study
mortality

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Santé publique et épidémiologie

Résumé en anglais : [en]

Aim: To test the association of alcohol consumption with total and cause-specific mortality risk.Design: Prospective observational multi-centre population-based study.Setting: Sixteen cohorts (15 from Europe) in the MOnica ...
Lire la suite >Aim: To test the association of alcohol consumption with total and cause-specific mortality risk.Design: Prospective observational multi-centre population-based study.Setting: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.Participants: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).Measurements: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.Findings: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.Conclusions: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL