Titre :

Early liver transplantation for severe acute alcohol-related hepatitis after more than a decade of experience.

Auteur(s) :

Germani, Giacomo [Auteur]
Università degli Studi di Padova = University of Padua [Unipd]
Mathurin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lucey, Michael R. [Auteur]
University of Wisconsin School of Medicine and Public Health
Trotter, James [Auteur]
Baylor University

Titre de la revue :

Journal of Hepatology

Nom court de la revue :

J Hepatol

Numéro :

78

Pagination :

1130-1136

Date de publication :

2023-05-21

ISSN :

1600-0641

Mot(s)-clé(s) en anglais :

Liver transplantation
alcohol-related hepatitis
alcohol-related liver disease
patient survival
return to alcohol use
LDLT

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

In patients with severe acute alcohol-related hepatitis not responding to medical therapy, early liver transplantation (LT) represents the only effective therapy and, when performed within strict and well-defined protocols, ...
Lire la suite >In patients with severe acute alcohol-related hepatitis not responding to medical therapy, early liver transplantation (LT) represents the only effective therapy and, when performed within strict and well-defined protocols, it is associated with a clear survival benefit and acceptable rates of return to alcohol use after transplantation. However, there is still high variability in access to LT for patients with severe alcohol-related hepatitis, mainly due to a persistent overemphasis in the pre-LT evaluation on duration of pre-transplant abstinence and the stigma that patients with alcohol-related liver disease often experience, leading to marked inequity of access to this potentially lifesaving procedure and negative health outcomes. Therefore, there is an increasing need for prospective multicentre studies focusing on pre-transplant selection practices and on better interventions to treat alcohol use disorder after LT.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-11T22:38:21Z
2024-03-27T10:18:41Z