The European landscape on allogeneic ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
URL permanente :
Titre :
The European landscape on allogeneic haematopoeietic cell transplantation in Chronic Lymphocytic Leukaemia between 2009 and 2019: a perspective from the Chronic Malignancies Working Party of the EBMT.
Auteur(s) :
Tournilhac, Olivier [Auteur]
CHU Estaing [Clermont-Ferrand]
Van Gelder, Michel [Auteur]
Maastricht University Medical Centre [MUMC]
Eikema, Dirk-Jan [Auteur]
Leiden University Medical Center [LUMC]
Zinger, Nienke [Auteur]
Leiden University Medical Center [LUMC]
Dreger, Peter [Auteur]
Universität Heidelberg [Heidelberg] = Heidelberg University
Bornhäuser, Martin [Auteur]
Technische Universität Dresden = Dresden University of Technology [TU Dresden]
Vucinic, Vladan [Auteur]
Scheid, Christof [Auteur]
University Hospital of Cologne [Cologne]
Cornelissen, Jan J. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Schroeder, Thomas [Auteur]
University Children's Hospital of Essen
Jindra, Pavel [Auteur]
Medicine Charles University and General Faculty Hospital in Prague
Sengeloev, Henrik [Auteur]
Rigshospitalet [Copenhagen]
Nguyen Quoc, Stephanie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Stelljes, Matthias [Auteur]
University Hospital Hamburg-Eppendorf
Blau, Igor Wolfgang [Auteur]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Mayer, Jiri [Auteur]
University Hospital Brno
Paneesha, Shankara [Auteur]
University Hospitals Birmingham [Birmingham, Royaume-Uni]
Chevallier, Patrice [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Forcade, Edouard [Auteur]
CHU Bordeaux
Kröger, Nicolaus [Auteur]
University Hospital Hamburg-Eppendorf
Blaise, Didier [Auteur]
Aix Marseille Université [AMU]
Gribben, John [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Nielsen, Bendt [Auteur]
Aarhus University Hospital
Johansson, Jan-Erik [Auteur]
Sahlgrenska University Hospital [Gothenburg]
Kyriakou, Charalampia [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Beguin, Yves [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Pioltelli, Pietro [Auteur]
Fondazione MBBM-Ospedale [Monza, Italie]
Sampol, Antònia [Auteur]
Mclornan, Donal P. [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Schetelig, Johannes [Auteur]
University Hospital Carl Gustav Carus [Dresden, Germany]
Hayden, Patrick J. [Auteur]
Trinity College Dublin
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
CHU Estaing [Clermont-Ferrand]
Van Gelder, Michel [Auteur]
Maastricht University Medical Centre [MUMC]
Eikema, Dirk-Jan [Auteur]
Leiden University Medical Center [LUMC]
Zinger, Nienke [Auteur]
Leiden University Medical Center [LUMC]
Dreger, Peter [Auteur]
Universität Heidelberg [Heidelberg] = Heidelberg University
Bornhäuser, Martin [Auteur]
Technische Universität Dresden = Dresden University of Technology [TU Dresden]
Vucinic, Vladan [Auteur]
Scheid, Christof [Auteur]
University Hospital of Cologne [Cologne]
Cornelissen, Jan J. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Schroeder, Thomas [Auteur]
University Children's Hospital of Essen
Jindra, Pavel [Auteur]
Medicine Charles University and General Faculty Hospital in Prague
Sengeloev, Henrik [Auteur]
Rigshospitalet [Copenhagen]
Nguyen Quoc, Stephanie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Stelljes, Matthias [Auteur]
University Hospital Hamburg-Eppendorf
Blau, Igor Wolfgang [Auteur]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Mayer, Jiri [Auteur]
University Hospital Brno
Paneesha, Shankara [Auteur]
University Hospitals Birmingham [Birmingham, Royaume-Uni]
Chevallier, Patrice [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Forcade, Edouard [Auteur]
CHU Bordeaux
Kröger, Nicolaus [Auteur]
University Hospital Hamburg-Eppendorf
Blaise, Didier [Auteur]
Aix Marseille Université [AMU]
Gribben, John [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Nielsen, Bendt [Auteur]
Aarhus University Hospital
Johansson, Jan-Erik [Auteur]
Sahlgrenska University Hospital [Gothenburg]
Kyriakou, Charalampia [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Beguin, Yves [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Pioltelli, Pietro [Auteur]
Fondazione MBBM-Ospedale [Monza, Italie]
Sampol, Antònia [Auteur]
Mclornan, Donal P. [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Schetelig, Johannes [Auteur]
University Hospital Carl Gustav Carus [Dresden, Germany]
Hayden, Patrick J. [Auteur]
Trinity College Dublin
Yakoub-Agha, Ibrahim [Auteur]
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Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Titre de la revue :
Bone Marrow Transplantation
Nom court de la revue :
Bone Marrow Transplant
Pagination :
1-4
Date de publication :
2023-03-30
ISSN :
1476-5365
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized ...
Lire la suite >Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized CLL management, allowing prolonged control to patients who have failed immunochemotherapy and/or have TP53 alterations. We analysed the pre COVID pandemic 2009–2019 EBMT registry. The yearly number of allo-HCT raised to 458 in 2011 yet dropped from 2013 onwards to an apparent plateau above 100. Within the 10 countries who were under the EMA for drug approval and performed 83.5% of those procedures, large initial differences were found but the annual number converged to 2–3 per 10 million inhabitants during the 3 most recent years suggesting that allo-HCT remains applied in selected patients. Long-term follow-up on targeted therapies shows that most patients relapse, some early, with risk factors and resistance mechanisms being described. The treatment of patients exposed to both BCL2 and BTK inhibitors and especially those with double refractory disease will become a challenge in which allo-HCT remains a solid option in competition with emerging therapies that have yet to demonstrate their long-term effectiveness.Lire moins >
Lire la suite >Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized CLL management, allowing prolonged control to patients who have failed immunochemotherapy and/or have TP53 alterations. We analysed the pre COVID pandemic 2009–2019 EBMT registry. The yearly number of allo-HCT raised to 458 in 2011 yet dropped from 2013 onwards to an apparent plateau above 100. Within the 10 countries who were under the EMA for drug approval and performed 83.5% of those procedures, large initial differences were found but the annual number converged to 2–3 per 10 million inhabitants during the 3 most recent years suggesting that allo-HCT remains applied in selected patients. Long-term follow-up on targeted therapies shows that most patients relapse, some early, with risk factors and resistance mechanisms being described. The treatment of patients exposed to both BCL2 and BTK inhibitors and especially those with double refractory disease will become a challenge in which allo-HCT remains a solid option in competition with emerging therapies that have yet to demonstrate their long-term effectiveness.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Date de dépôt :
2024-01-11T23:06:25Z
2024-03-11T10:49:24Z
2024-03-11T10:49:24Z