Health Outcome of 215 Mothers of Children ...
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Article dans une revue scientifique: Article original
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Title :
Health Outcome of 215 Mothers of Children with Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry.
Author(s) :
Miniaoui, Imene [Auteur]
Morel, Nathalie [Auteur]
Hôpital Cochin [AP-HP]
Lévesque, Kateri [Auteur]
Maltret, Alice [Auteur]
Centre de Référence Malformations Cardiaques Congénitales Complexes [M3C]
Driessen, Marine [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Masseau, Agathe [Auteur]
Hôtel-Dieu de Nantes
Orquevaux, Pauline [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Piette, Jean-Charles [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Barriere, François [Auteur]
Urgences pédiatriques [Hôpital de la Timone - APHM]
Le Bidois, Jerome [Auteur]
Centre de Référence Malformations Cardiaques Congénitales Complexes [M3C]
Georgin-Lavialle, Sophie [Auteur]
CHU Tenon [AP-HP]
Guettrot-Imbert, Gaëlle [Auteur]
Hôpital Cochin [AP-HP]
Le Guern, Véronique [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Hôpital Cochin [AP-HP]
Mouthon, Luc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Jallouli, Moez [Auteur]
Hôpital Cochin [AP-HP]
Deligny, Christophe [Auteur]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Romefort, Benedicte [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Bonnet, Damien [Auteur]
Centre de Référence M3C Malformations Cardiaques Congénitales Complexes [CHU Necker] [CARPEDEM-M3C]
Costedoat-Chalumeau, Nathalie [Auteur]
Clinical Epidemiology Applied to Osteoarticular Diseases | Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques [ ECaMO - [CRESS - U1153 / UMR_A 1125]]
Morel, Nathalie [Auteur]
Hôpital Cochin [AP-HP]
Lévesque, Kateri [Auteur]
Maltret, Alice [Auteur]
Centre de Référence Malformations Cardiaques Congénitales Complexes [M3C]
Driessen, Marine [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Masseau, Agathe [Auteur]
Hôtel-Dieu de Nantes
Orquevaux, Pauline [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Piette, Jean-Charles [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Barriere, François [Auteur]
Urgences pédiatriques [Hôpital de la Timone - APHM]
Le Bidois, Jerome [Auteur]
Centre de Référence Malformations Cardiaques Congénitales Complexes [M3C]
Georgin-Lavialle, Sophie [Auteur]
CHU Tenon [AP-HP]
Guettrot-Imbert, Gaëlle [Auteur]
Hôpital Cochin [AP-HP]
Le Guern, Véronique [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Hôpital Cochin [AP-HP]
Mouthon, Luc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Jallouli, Moez [Auteur]
Hôpital Cochin [AP-HP]
Deligny, Christophe [Auteur]
Hachulla, Eric [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Romefort, Benedicte [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Bonnet, Damien [Auteur]
Centre de Référence M3C Malformations Cardiaques Congénitales Complexes [CHU Necker] [CARPEDEM-M3C]
Costedoat-Chalumeau, Nathalie [Auteur]
Clinical Epidemiology Applied to Osteoarticular Diseases | Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques [ ECaMO - [CRESS - U1153 / UMR_A 1125]]
Journal title :
Journal of Rheumatology
Abbreviated title :
J Rheumatol
Volume number :
49
Pages :
1124-1130
Publication date :
2022-05-05
ISSN :
0315-162X
English keyword(s) :
anti-SSA/Ro antibodies
congenital heart block
maternal diseases
neonatal lupus erythematosus syndrome
pregnancy
systemic lupus erythematosus
congenital heart block
maternal diseases
neonatal lupus erythematosus syndrome
pregnancy
systemic lupus erythematosus
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objective Transplacental passage of maternal anti-SSA and anti-SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we ...
Show more >Objective Transplacental passage of maternal anti-SSA and anti-SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB). Methods This retrospective study included anti-SSA/SSB antibody–positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter. Results We analyzed 215 women with at least 1 pregnancy with CHB. Prior to this diagnosis, only 52 (24%) mothers had been diagnosed with an autoimmune disease, mainly systemic lupus erythematosus (SLE; n = 26, 12%) and Sjögren syndrome (SS; n = 16, 7%). Six more were diagnosed with an autoimmune disease during the index pregnancy. Of the 157 mothers (73%) with no such diagnosis at childbirth, 77 (49%) developed one after a median follow-up of 11 years (range: 21 days to 54 years). By the end of follow-up, 135 women (63%) had an autoimmune disease diagnosis, mainly SLE (n = 54, 25%) and SS (n = 72, 33%). Three patients with SLE had renal involvement, and only 6 (3%) had required an immunosuppressive drug at any point. The symptoms best predicting autoimmune disease development were arthralgia and myalgia (P < 0.001), dry syndrome (P = 0.01), and parotid swelling (P = 0.05). Conclusion One-quarter of the patients had an autoimmune disease diagnosis at the time of the fetal CHB diagnosis. Nearly half of those without an initial diagnosis progressed during follow-up, most without severe manifestations. Severe diseases such as lupus nephritis were rarely seen, and immunosuppressive drugs were rarely required.Show less >
Show more >Objective Transplacental passage of maternal anti-SSA and anti-SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB). Methods This retrospective study included anti-SSA/SSB antibody–positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter. Results We analyzed 215 women with at least 1 pregnancy with CHB. Prior to this diagnosis, only 52 (24%) mothers had been diagnosed with an autoimmune disease, mainly systemic lupus erythematosus (SLE; n = 26, 12%) and Sjögren syndrome (SS; n = 16, 7%). Six more were diagnosed with an autoimmune disease during the index pregnancy. Of the 157 mothers (73%) with no such diagnosis at childbirth, 77 (49%) developed one after a median follow-up of 11 years (range: 21 days to 54 years). By the end of follow-up, 135 women (63%) had an autoimmune disease diagnosis, mainly SLE (n = 54, 25%) and SS (n = 72, 33%). Three patients with SLE had renal involvement, and only 6 (3%) had required an immunosuppressive drug at any point. The symptoms best predicting autoimmune disease development were arthralgia and myalgia (P < 0.001), dry syndrome (P = 0.01), and parotid swelling (P = 0.05). Conclusion One-quarter of the patients had an autoimmune disease diagnosis at the time of the fetal CHB diagnosis. Nearly half of those without an initial diagnosis progressed during follow-up, most without severe manifestations. Severe diseases such as lupus nephritis were rarely seen, and immunosuppressive drugs were rarely required.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Submission date :
2024-01-12T01:37:48Z
2024-03-15T09:28:23Z
2024-03-15T09:28:23Z