Title :

Association between birth weight, preterm birth and non-alcoholic fatty liver disease in a community-based cohort.

Author(s) :

Amadou, Coralie [Auteur]
UFR Médecine [Santé] - Université Paris Cité [UFR Médecine UPCité]
Nabi, Oumarou [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Serfaty, Lawrence [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Lacombe, Karine [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Boursier, Jerôme [Auteur]
Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques [HIFIH]
Mathurin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ribet, Céline [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
De Ledinghen, Victor [Auteur]
Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]
Zins, Marie [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Charles, Marie-Aline [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]

Journal title :

Hepatology

Abbreviated title :

Hepatology

Volume number :

76

Pages :

1438-1451

Publication date :

2022-04-29

ISSN :

1527-3350

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and Aims The association between birth weight (BW) and metabolic outcomes has been described since the 1980s but NAFLD has been rarely studied. This study aimed to investigate the association between BW and ...
Show more >Background and Aims The association between birth weight (BW) and metabolic outcomes has been described since the 1980s but NAFLD has been rarely studied. This study aimed to investigate the association between BW and NAFLD occurrence in adult subjects. Approach and Results The study population consisted of participants from the French nationwide Constances cohort from 2012 to 2019. Participants with a history of chronic viral hepatitis or excessive alcohol consumption were excluded. Noninvasive diagnosis of NAFLD and fibrosis was performed using a combination of the Fatty Liver Index (FLI) and the Forns Index. The relationship between BW and NAFLD was analyzed with a sex‐stratified logistic regression model adjusted for sociodemographic parameters, lifestyle, and birth term, whereas liver fibrosis was analyzed with a sex‐stratified linear regression model. In total, 55,034 individuals with reliable BW were included (43% men, mean age: 38 years). NAFLD (FLI ≥ 60) was present in 5530 individuals (10%). Multivariate logistic regression showed a significant U‐shaped relationship between BW and NAFLD, with no significant interaction with sex. A significant and slightly decreasing association was found between BW and Forns Index (β = −0.05; p = 0.04). Premature birth (OR, 1.23; 95% CI, 1.03–1.48 for birth between 33 and 37 weeks versus ≥ 37 weeks) was associated with NAFLD, with a significant direct effect of premature birth, and without an indirect effect of low BW in mediation analysis. Forns Index was not significantly higher in participants with preterm birth compared to full‐term birth. Conclusions This large prospective adult‐based cohort confirms the relationship between BW and NAFLD occurrence.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-12T01:39:59Z
2024-03-21T07:14:13Z
2024-03-22T08:11:41Z