Safety evaluation of food enzyme trypsin ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Safety evaluation of food enzyme trypsin from porcine pancreas.
Auteur(s) :
Lambré, C. [Auteur]
European Food Safety Authority [EFSA]
Barat Baviera, J. M. [Auteur]
Bolognesi, C. [Auteur]
Cocconcelli, P. S. [Auteur]
Crebelli, R. [Auteur]
Gott, D. M. [Auteur]
Grob, K. [Auteur]
Lampi, E. [Auteur]
Mengelers, M. [Auteur]
Mortensen, A. [Auteur]
Rivière, G. [Auteur]
Steffensen, I. L. [Auteur]
Tlustos, C. [Auteur]
Van Loveren, H. [Auteur]
Vernis, L. [Auteur]
Zorn, H. [Auteur]
Gundert-Remy, U. [Auteur]
Herman, L. [Auteur]
Turck, Dominique [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Engel, K. H. [Auteur]
Aguilera-Gómez, M. [Auteur]
Andryszkiewicz, M. [Auteur]
Kovalkovicova, N. [Auteur]
Liu, Y. [Auteur]
Maia, J. [Auteur]
Rainieri, S. [Auteur]
Chesson, A. [Auteur]
European Food Safety Authority [EFSA]
Barat Baviera, J. M. [Auteur]
Bolognesi, C. [Auteur]
Cocconcelli, P. S. [Auteur]
Crebelli, R. [Auteur]
Gott, D. M. [Auteur]
Grob, K. [Auteur]
Lampi, E. [Auteur]
Mengelers, M. [Auteur]
Mortensen, A. [Auteur]
Rivière, G. [Auteur]
Steffensen, I. L. [Auteur]
Tlustos, C. [Auteur]
Van Loveren, H. [Auteur]
Vernis, L. [Auteur]
Zorn, H. [Auteur]
Gundert-Remy, U. [Auteur]
Herman, L. [Auteur]
Turck, Dominique [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Engel, K. H. [Auteur]
Aguilera-Gómez, M. [Auteur]
Andryszkiewicz, M. [Auteur]
Kovalkovicova, N. [Auteur]
Liu, Y. [Auteur]
Maia, J. [Auteur]
Rainieri, S. [Auteur]
Chesson, A. [Auteur]
Titre de la revue :
EFSA Journal
Nom court de la revue :
EFSA J
Numéro :
19
Pagination :
e06637
Date de publication :
2021-07-03
ISSN :
1831-4732
Mot(s)-clé(s) en anglais :
pig
porcine pancreas
EC 3.4.21.4
trypsin
Food enzyme
porcine pancreas
EC 3.4.21.4
trypsin
Food enzyme
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The food enzyme trypsin (EC 3.4.21.4) is extracted from porcine pancreas by Novozymes A/S. Thefood enzyme is intended to be used for hydrolysis of whey proteins employed as ingredients in infantformulae, follow-on formulae ...
Lire la suite >The food enzyme trypsin (EC 3.4.21.4) is extracted from porcine pancreas by Novozymes A/S. Thefood enzyme is intended to be used for hydrolysis of whey proteins employed as ingredients in infantformulae, follow-on formulae and in food for special medical purposes. Based on maximum use levelsand the maximum permitted protein content in infant formula, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be 32 mg TOS/kg body weight (bw) per day for infants.The Panel considered that this value covers all population groups consuming these formulae. In thetoxicological evaluation, clinical studies with pancreatic enzymes were considered. Hypersensitivity tothe pharmaceuticals was identified as the major side effect. However, allergic reactions to porcinepancreatic enzymes in hydrolysed foods have not been reported. The Panel considered that a risk ofallergic sensitisation to this food enzyme after consumption of products prepared by hydrolysis of milkcould not be excluded in infants but considered the likelihood to be low. Based on the origin of thefood enzyme from edible parts of animals, the data provided by the applicant and supported by theevaluation of clinical studies based on pancreatic enzymes and the estimated dietary exposure,the Panel concluded that the trypsin from porcine pancreas does not give rise to safety concern underthe intended conditions of use.Lire moins >
Lire la suite >The food enzyme trypsin (EC 3.4.21.4) is extracted from porcine pancreas by Novozymes A/S. Thefood enzyme is intended to be used for hydrolysis of whey proteins employed as ingredients in infantformulae, follow-on formulae and in food for special medical purposes. Based on maximum use levelsand the maximum permitted protein content in infant formula, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be 32 mg TOS/kg body weight (bw) per day for infants.The Panel considered that this value covers all population groups consuming these formulae. In thetoxicological evaluation, clinical studies with pancreatic enzymes were considered. Hypersensitivity tothe pharmaceuticals was identified as the major side effect. However, allergic reactions to porcinepancreatic enzymes in hydrolysed foods have not been reported. The Panel considered that a risk ofallergic sensitisation to this food enzyme after consumption of products prepared by hydrolysis of milkcould not be excluded in infants but considered the likelihood to be low. Based on the origin of thefood enzyme from edible parts of animals, the data provided by the applicant and supported by theevaluation of clinical studies based on pancreatic enzymes and the estimated dietary exposure,the Panel concluded that the trypsin from porcine pancreas does not give rise to safety concern underthe intended conditions of use.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Date de dépôt :
2024-01-12T06:32:38Z
2024-03-01T13:37:49Z
2024-03-01T13:37:49Z
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- EFSA Journal - 2021 - - Safety evaluation of food enzyme trypsin from porcine pancreas.pdf
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