Titre :

Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke.

Auteur(s) :

Exalto, Lieza G. [Auteur]
Utrecht Brain Center [UMC]
Weaver, N. A. [Auteur]
Kuijf, H. J. [Auteur]
Aben, H. P. [Auteur]
Bae, H. J. [Auteur]
Best, J. G. [Auteur]
Bordet, Regis [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Chen, C. P. L. H. [Auteur]
Van Der Giessen, R. S. [Auteur]
Godefroy, O. [Auteur]
Gyanwali, B. [Auteur]
Hamilton, O. K. L. [Auteur]
Hilal, S. [Auteur]
Huenges Wajer, I. M. C. [Auteur]
Kim, J. [Auteur]
Kappelle, L. J. [Auteur]
Kim, B. J. [Auteur]
Köhler, S. [Auteur]
De Kort, P. L. M. [Auteur]
Koudstaal, P. J. [Auteur]
Lim, J. S. [Auteur]
Makin, S. D. J. [Auteur]
Mok, V. C. T. [Auteur]
Van Oostenbrugge, R. J. [Auteur]
Roussel, M. [Auteur]
Staals, J. [Auteur]
Valdés-Hernández, M. D. C. [Auteur]
Venketasubramanian, N. [Auteur]
Verhey, F. R. J. [Auteur]
Wardlaw, J. M. [Auteur]
Werring, D. J. [Auteur]
Xu, X. [Auteur]
Van Zandvoort, M. J. E. [Auteur]
Biesbroek, J. M. [Auteur]
Chappell, F. M. [Auteur]
Biessels, G. J. [Auteur]

Titre de la revue :

Stroke

Nom court de la revue :

Stroke

Numéro :

54

Pagination :

2296–2303

Éditeur :

American Heart Association

Date de publication :

2023-08-09

ISSN :

1524-4628

Mot(s)-clé(s) :

cognition
ischemic stroke
men
survivors
women

Mot(s)-clé(s) en anglais :

women
survivors
men
ischemic stroke
cognition

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: Poststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes of stroke are worse in women than men. Yet it is unknown whether the ...
Lire la suite >BACKGROUND: Poststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes of stroke are worse in women than men. Yet it is unknown whether the occurrence and characteristics of PSCI differ between men and women. METHODS: Individual patient data from 9 cohorts of patients with ischemic stroke were harmonized and pooled through the Meta-VCI-Map consortium (n=2343, 38% women). We included patients with visible symptomatic infarcts on computed tomography/magnetic resonance imaging and cognitive assessment within 15 months after stroke. PSCI was defined as impairment in ≥1 cognitive domains on neuropsychological assessment. Logistic regression analyses were performed to compare men to women, adjusted for study cohort, to obtain odds ratios for PSCI and individual cognitive domains. We also explored sensitivity and specificity of cognitive screening tools for detecting PSCI, according to sex (Mini-Mental State Examination, 4 cohorts, n=1814; Montreal Cognitive Assessment, 3 cohorts, n=278). RESULTS: PSCI was found in 51% of both women and men. Men had a lower risk of impairment of attention and executive functioning (men: odds ratio, 0.76 [95% CI, 0.61–0.96]), and language (men: odds ratio, 0.67 [95% CI, 0.45–0.85]), but a higher risk of verbal memory impairment (men: odds ratio, 1.43 [95% CI, 1.17–1.75]). The sensitivity of Mini-Mental State Examination (<25) for PSCI was higher for women (0.53) than for men (0.27; P=0.02), with a lower specificity for women (0.80) than men (0.96; P=0.01). Sensitivity and specificity of Montreal Cognitive Assessment (<26.) for PSCI was comparable between women and men (0.91 versus 0.86; P=0.62 and 0.29 versus 0.28; P=0.86, respectively). CONCLUSIONS: Sex was not associated with PSCI occurrence but affected domains differed between men and women. The latter may explain why sensitivity of the Mini-Mental State Examination for detecting PSCI was higher in women with a lower specificity compared with men. These sex differences need to be considered when screening for and diagnosing PSCI in clinical practice.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:34:19Z
2024-07-10T09:07:20Z