Titre :

Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19.

Auteur(s) :

Scutelnic, A. [Auteur]
Van De Munckhof, A. [Auteur]
Krzywicka, K. [Auteur]
Van Kammen, M. S. [Auteur]
Lindgren, E. [Auteur]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Kleinig, T. J. [Auteur]
Field, T. S. [Auteur]
Poli, S. [Auteur]
Lemmens, R. [Auteur]
Middeldorp, S. [Auteur]
Aaron, S. [Auteur]
Borhani-Haghighi, A. [Auteur]
Arauz, A. [Auteur]
Kremer Hovinga, J. A. [Auteur]
Günther, A. [Auteur]
Putaala, J. [Auteur]
Wasay, M. [Auteur]
Conforto, A. B. [Auteur]
De Sousa, D. A. [Auteur]
Jood, K. [Auteur]
Tatlisumak, T. [Auteur]
Ferro, J. M. [Auteur]
Coutinho, J. M. [Auteur]
Arnold, Marcel [Auteur]
Universität Bern = University of Bern = Université de Berne [UNIBE]
Heldner, M. R. [Auteur]

Titre de la revue :

European Stroke Journal

Nom court de la revue :

Eur Stroke J

Numéro :

8

Pagination :

23969873231185213

Éditeur :

SAGE Journals

Date de publication :

2023-07-12

ISSN :

2396-9881

Mot(s)-clé(s) :

VITT
CVST
sex differences

Mot(s)-clé(s) en anglais :

sex differences
CVST
VITT

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. ...
Lire la suite >Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:39:38Z
2024-10-23T09:31:17Z