Titre :

Atypical White Matter Hyperintensities Markedly Impact Plasma Neurofilament Light Chain Variability in GRN Patients.

Auteur(s) :

Vítor, J. [Auteur]
Saracino, D. [Auteur]
Ströer, S. [Auteur]
Camuzat, A. [Auteur]
Dorgham, K. [Auteur]
Clot, F. [Auteur]
Martin-Hardy, P. [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Le Ber, Isabelle [Auteur]
CHU Pitié-Salpêtrière [AP-HP]

Titre de la revue :

Journal of Alzheimer's Disease

Numéro :

94

Pagination :

1351-1360

Éditeur :

Sage

Date de publication :

2023-07-03

ISSN :

1875-8908

Mot(s)-clé(s) :

Amyotrophic lateral sclerosis
frontotemporal dementia
frontotemporal lobar degeneration
GRN
leukopathy
neurofilament light chain
progranulin
white matter hyperintensities

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

GRN mutations, causing frontotemporal dementia, can be associated with atypical white matter hyperintensities (WMH). We hypothesized that the presence of WMH may impact neurofilament light chain (NfL) levels, markers of ...
Lire la suite >GRN mutations, causing frontotemporal dementia, can be associated with atypical white matter hyperintensities (WMH). We hypothesized that the presence of WMH may impact neurofilament light chain (NfL) levels, markers of neuroaxonal damage. We analyzed plasma NfL in 20 GRN patients and studied their association to visually-scored WMH burden. The 12 patients displaying atypical WMH had significantly higher NfL levels (98.4±34.9 pg/mL) than those without WMH (47.2±29.4 pg/mL, p = 0.003), independently from age, disease duration and Fazekas-Schmidt grade. NfL correlated with WMH burden (rho = 0.55, p = 0.01). This study prompts considering WMH burden as a variability factor when evaluating NfL levels in GRN patients.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:42:55Z
2024-09-25T07:43:26Z