Titre :

The contribution of executive control dysfunction to freezing of gait in Parkinson's disease.

Auteur(s) :

Bayot, Madli [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Gerard, Morgane [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Braquet, A. [Auteur]
Médipôle Lyon-Villeurbanne [MLV]
Tard, Celine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Betrouni, Nacim [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Delval, Arnaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

Clin Neurophysiol

Numéro :

152

Pagination :

75-89

Date de publication :

2023-06-26

ISSN :

1872-8952

Mot(s)-clé(s) :

Parkinson's disease (PD)
Freezing of gait (FoG)
Step initiation
Attention Network Test (ANT)
Electroencephalography (EEG)

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objective An executive dysfunction is supposed to contribute to freezing of gait (FoG) in Parkinson’s disease. We aimed to investigate at a behavioral and cortical levels whether an attentional load (particularly, a ...
Lire la suite >Objective An executive dysfunction is supposed to contribute to freezing of gait (FoG) in Parkinson’s disease. We aimed to investigate at a behavioral and cortical levels whether an attentional load (particularly, a conflicting situation) can specifically impact preparation and execution phases of step initiation in parkinsonian patients with FoG. Methods Fifteen patients with FoG, 16 without and 15 controls performed an adapted version of the Attention Network Test, with step initiation as response instead of the standard manual keypress. Kinetic and kinematic features of gait initiation as well as high-resolution electroencephalography were recorded during the task. Results Patients with FoG presented an impaired executive control. Step execution time was longer in parkinsonian patients. However, the executive control effect on step execution time was not different between all groups. Compared to patients, controls showed a shorter step initiation-locked alpha desynchronization, and an earlier, more intense and shorter beta desynchronization over the sensorimotor cortex. Even though controls were faster, the induced alpha and beta activity associated with the effect of executive control didn’t differ between patients and controls. Conclusions Tasks of conflict resolution lead to a comparable alteration of step initiation and its underlying brain activity in all groups. Links between executive control, gait initiation and FoG seem more complex than expected. Significance This study questions the cognitive hypothesis in the pathophysiology of freezing of gait. Executive dysfunction is associated with FoG but is not the main causal mechanism since the interaction between attention and motor preparation didn’t provoke FoG.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:45:44Z
2024-11-22T10:02:08Z