Titre :

Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration.

Auteur(s) :

Traenka, C. [Auteur]
Lorscheider, J. [Auteur]
Hametner, C. [Auteur]
Baumgartner, P. [Auteur]
Gralla, J. [Auteur]
Magoni, M. [Auteur]
Martinez-Majander, N. [Auteur]
Casolla, Barbara [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Feil, K. [Auteur]
Pascarella, R. [Auteur]
Papanagiotou, P. [Auteur]
Nordanstig, A. [Auteur]
Padjen, V. [Auteur]
Cereda, C. W. [Auteur]
Psychogios, M. [Auteur]
Nolte, C. H. [Auteur]
Zini, A. [Auteur]
Michel, P. [Auteur]
Béjot, Y. [Auteur]
Kastrup, A. [Auteur]
Zedde, M. [Auteur]
Kägi, G. [Auteur]
Kellert, L. [Auteur]
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Curtze, S. [Auteur]
Pezzini, A. [Auteur]
Arnold, M. [Auteur]
Wegener, S. [Auteur]
Ringleb, P. [Auteur]
Tatlisumak, T. [Auteur]
Nederkoorn, P. J. [Auteur]
Engelter, S. T. [Auteur]
Gensicke, H. [Auteur]

Titre de la revue :

Journal of Stroke

Nom court de la revue :

J Stroke

Numéro :

25

Pagination :

272-281

Éditeur :

Korean Stroke Society

Date de publication :

2023-06-08

ISSN :

2287-6391

Mot(s)-clé(s) :

Thrombolysis
Endovascular treatment
Stroke
Cervical artery dissection

Mot(s)-clé(s) en anglais :

Thrombolysis
Endovascular treatment
Stroke
Cervical artery dissection

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background and Purpose This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) ...
Lire la suite >Background and Purpose This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD). Methods This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching. Results Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P<0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; ORadjusted 0.56 [0.24-1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; ORadjusted 8.85 [4.28-18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group. Conclusion We observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-characteristics or their younger age might explain this observation deserves further research.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:52:59Z
2024-09-25T06:33:59Z