Developmental programming of hypothalamic melanocortin circuits.

Bouret, Sebastien

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1038/s12276-021-00625-8

PMID :

35474338

Permalink :

http://hdl.handle.net/20.500.12210/101999

Title :

Developmental programming of hypothalamic melanocortin circuits.

Author(s) :

Bouret, Sebastien [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Experimental and Molecular Medicine

Volume number :

Pages :

403–413

Publication date :

2022-05-05

ISSN :

2092-6413

HAL domain(s) :

Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie

English abstract : [en]

The melanocortin system plays a critical role in the central regulation of food intake and energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC), melanocortin receptors (MC4Rs), and the ...
Show more >The melanocortin system plays a critical role in the central regulation of food intake and energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC), melanocortin receptors (MC4Rs), and the endogenous antagonist agouti-related peptide (AgRP). Pomc and Mc4r deficiency in rodents and humans causes early onset of obesity, whereas a loss of Agrp function is associated with leanness. Accumulating evidence shows that many chronic diseases, including obesity, might originate during early life. The melanocortin system develops during a relatively long period beginning during embryonic life with the birth of POMC and AgRP neurons and continuing postnatally with the assembly of their neuronal circuitry. The development of the melanocortin system requires the tight temporal regulation of molecular factors, such as transcription factors and axon guidance molecules, and cellular mechanisms, such as autophagy. It also involves a complex interplay of endocrine and nutritional factors. The disruption of one or more of these developmental factors can lead to abnormal maturation and function of the melanocortin system and has profound metabolic consequences later in life.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-16T01:16:07Z
2024-07-01T08:29:36Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/101999*	2024-07-01T08:28:00Z
1	20.500.12210/101999.1	2024-01-16T01:16:07Z

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Developmental programming of hypothalamic ...

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