Developmental programming of hypothalamic melanocortin circuits.

Bouret, Sebastien

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1038/s12276-021-00625-8

PMID :

35474338

URL permanente :

http://hdl.handle.net/20.500.12210/101999

Titre :

Developmental programming of hypothalamic melanocortin circuits.

Auteur(s) :

Bouret, Sebastien [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

Experimental and Molecular Medicine

Numéro :

Pagination :

403–413

Date de publication :

2022-05-05

ISSN :

2092-6413

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie

Résumé en anglais : [en]

The melanocortin system plays a critical role in the central regulation of food intake and energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC), melanocortin receptors (MC4Rs), and the ...
Lire la suite >The melanocortin system plays a critical role in the central regulation of food intake and energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC), melanocortin receptors (MC4Rs), and the endogenous antagonist agouti-related peptide (AgRP). Pomc and Mc4r deficiency in rodents and humans causes early onset of obesity, whereas a loss of Agrp function is associated with leanness. Accumulating evidence shows that many chronic diseases, including obesity, might originate during early life. The melanocortin system develops during a relatively long period beginning during embryonic life with the birth of POMC and AgRP neurons and continuing postnatally with the assembly of their neuronal circuitry. The development of the melanocortin system requires the tight temporal regulation of molecular factors, such as transcription factors and axon guidance molecules, and cellular mechanisms, such as autophagy. It also involves a complex interplay of endocrine and nutritional factors. The disruption of one or more of these developmental factors can lead to abnormal maturation and function of the melanocortin system and has profound metabolic consequences later in life.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-16T01:16:07Z
2024-07-01T08:29:36Z

Fichiers

s12276-021-00625-8.pdf
Non spécifié
Accès libre
Accéder au document

Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/101999*	2024-07-01T08:28:00Z
1	20.500.12210/101999.1	2024-01-16T01:16:07Z

Developmental programming of hypothalamic ...

BibTeX

CSV

Excel

RIS

Fichiers

Historique des modifications

Developmental programming of hypothalamic ... BibTeX CSV Excel RIS

Fichiers

Historique des modifications

Developmental programming of hypothalamic ...

BibTeX

CSV

Excel

RIS