Titre :

ESO Guideline on covert cerebral small vessel disease

Auteur(s) :

Wardlaw, Joanna M. [Auteur]
Debette, Stephanie [Auteur]
Université de Bordeaux [UB]
Jokinen, Hanna [Auteur]
De Leeuw, Frank-Eric [Auteur]
Pantoni, Leonardo [Auteur]
Chabriat, Hugues [Auteur]
Staals, Julie [Auteur]
Doubal, Fergus [Auteur]
Rudilosso, Salvatore [Auteur]
Eppinger, Sebastian [Auteur]
Schilling, Sabrina [Auteur]
Université de Bordeaux [UB]
Ornello, Raffaele [Auteur]
Enzinger, Christian [Auteur]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Taylor-Rowan, Martin [Auteur]
Lindgren, Arne G. [Auteur]

Titre de la revue :

European Stroke Journal

Numéro :

6

Pagination :

CXI - CLXII

Date de publication :

2021-06

ISSN :

2396-9873

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death. These ...
Lire la suite >‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist with clinical decisions about management of ccSVD, specifically white matter hyperintensities and lacunes, to prevent adverse clinical outcomes. The guidelines were developed according to ESO standard operating procedures and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. We prioritised the clinical outcomes of stroke, cognitive decline or dementia, dependency, death, mobility and mood disorders, and interventions of blood pressure lowering, antiplatelet drugs, lipid lowering, lifestyle modifications, glucose lowering and conventional treatments for dementia. We systematically reviewed the literature, assessed the evidence, formulated evidence-based recommendations where feasible, and expert consensus statements. We found little direct evidence, mostly of low quality. We recommend patients with ccSVD and hypertension to have their blood pressure well controlled; lower blood pressure targets may reduce ccSVD progression. We do not recommend antiplatelet drugs such as aspirin in ccSVD. We found little evidence on lipid lowering in ccSVD. Smoking cessation is a health priority. We recommend regular exercise which may benefit cognition, and a healthy diet, good sleep habits, avoiding obesity and stress for general health reasons. In ccSVD, we found no evidence for glucose control in the absence of diabetes or for conventional Alzheimer dementia treatments. Randomised controlled trials with clinical endpoints are a priority for ccSVD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-16T01:51:21Z
2024-11-25T14:06:52Z