Titre :

Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?

Auteur(s) :

Betka, Sophie [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Brighton and Sussex Medical School [BSMS]
Gould Van Praag, Cassandra [Auteur]
Paloyelis, Yannis [Auteur]
Bond, Rod [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]

Titre de la revue :

Social Cognitive and Affective Neuroscience

Numéro :

13

Pagination :

p.440-448

Éditeur :

Oxford University Press (OUP)

Date de publication :

2018-03-28

Mot(s)-clé(s) en anglais :

alcohol
addiction
alcohol use
oxytocin
interoception
attention

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission ...
Lire la suite >Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission of bodily signals and, through its potential modulation of craving, is proposed as a possible treatment for alcohol use disorders. However, oxytocin’s impact on interoception in alcohol users remains unknown. Healthy alcohol users (n = 32) attended two laboratory sessions to perform tests of interoceptive ability (heartbeat tracking: attending to internal signals and, heartbeat discrimination: integrating internal and external signals) after intranasal administration of oxytocin or placebo. Effects of interoceptive accuracy, oxytocin administration and alcohol intake, were tested using mixed-effects models. On the tracking task, oxytocin reduced interoceptive accuracy, but did not interact with alcohol consumption. On the discrimination task, we found an interaction between oxytocin administration and alcohol intake: Oxytocin, compared with placebo, increased interoceptive accuracy in heavy drinkers, but not in light social drinkers. Our study does not suggest a pure interoceptive impairment in alcohol users but instead potentially highlights reduced flexibility of internal and external attentional resource allocation. Importantly, this impairment seems to be mitigated by oxytocin. This attentional hypothesis needs to be explicitly tested in future research.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Dynamique Émotionnelle et Pathologies (DEEP)

Date de dépôt :

2024-01-17T14:46:12Z
2024-02-12T13:53:26Z
2024-02-16T07:24:31Z