Title :

Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs.

Author(s) :

Honkimaa, Anni [Auteur]
University of Tampere [Finland]
Sioofy-Khojine, Amir-Babak [Auteur]
University of Tampere [Finland]
Oikarinen, Sami [Auteur]
University of Tampere [Finland]
Bertin, Antoine [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Hyöty, Heikki [Auteur]
University of Tampere [Finland]

Journal title :

Journal of Clinical Virology

Abbreviated title :

J. Clin. Virol.

Volume number :

128

Pages :

104334

Publication date :

2020-06-06

ISSN :

1873-5967

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Persistent enterovirus infections create a difficult therapeutic challenge in immunocompromised patients and may also contribute to the development of chronic diseases including type 1 diabetes, cardiomyopathies, ...
Show more >Background Persistent enterovirus infections create a difficult therapeutic challenge in immunocompromised patients and may also contribute to the development of chronic diseases including type 1 diabetes, cardiomyopathies, post-polio syndrome and chronic fatigue syndrome. Objectives To study the ability of antiviral drugs to eradicate such infection in vitro to evalaute their potential in the treatments of these patients. Study design We set out to evaluate several licensed or clinically tested drugs which have shown some anti-enterovirus activity in previous studies for their ability to cure persistent infection established by two different coxsackievirus B1 strains in a pancreatic cell line (PANC-1 cells). Results Among all tested drugs Enviroxime, Fluoxetine, concentrated human IgG product (Hizentra) and Pleconaril were able to eradicate persistent Coxsackievirus B1 infection. The effect Enviroxime, Hizentra and Pleconaril varied between the two virus strains. Conclusions The identified drugs are feasible candidates for clinical trials among patients with persistent coxsackievirus B infections or chronic enterovirus-associated diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:21:53Z
2024-02-08T12:09:06Z